Seroatlas · Human Serome Atlas

WASHC1

WASH complex subunit 1

Also known as: FAM39E, FLJ00038, WASH1, WASH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8K0Z3
Gene: WASHC1
Ensembl: ENSG00000181404
Chromosome: 9
Canonical length: 465 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

Enables alpha-tubulin binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including Arp2/3 complex-mediated actin nucleation; endosomal transport; and positive regulation of pseudopodium assembly. Located in several cellular components, including endosome; exocyst; and lamellipodium. Part of WASH complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>A8K0Z3|WASHC1
     1  MTPVRMQHSL AGQTYAVPFI QPDLRREEAV QQMADALQYL QKVSGDIFSR ISQQVEQSRS
    61  QVQAIGEKVS LAQAKIEKIK GSKKAIKVFS SAKYPAPGRL QEYGSIFTGA QDPGLQRRPR
   121  HRIQSKHRPL DERALQEKLK DFPVCVSTKP EPEDDAEEGL GGLPSNISSV SSLLLFNTTE
   181  NLYKKYVFLD PLAGAVTKTH VMLGAETEEK LFDAPLSISK REQLEQQVPE NYFYVPDLGQ
   241  VPEIHVPSYL PDLPGIANDL MYSADLGPGI APSAPGTIPE LPTFHTEVAE PLKVDLQDGV
   301  LTPPPPPPPP PPAPEVLASA PPLPPSTAAP VGQGARQDDS SSSASPSVQG APREVVDPSG
   361  GWATLLESIR QAGGIGKAKL RSMKERKLEK QQQKEQEQVR ATSQGGHLMS DLFNKLVMRR
   421  KGISGKGPGA GEGPGGAFVR VSDSIPPLPP PQQPQAEEDE DDWES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WASHC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

spleen: 29 nTPM
fallopian tube: 28 nTPM
cerebellum: 28 nTPM
prostate: 26 nTPM
kidney: 25 nTPM
skin: 25 nTPM

Single-cell type

podocytes: 327 nCPM
proximal tubule cells: 145 nCPM
renal collecting duct principal cells: 125 nCPM
renal connecting tubule cells: 110 nCPM
renal collecting duct intercalated cells: 108 nCPM
distal convoluted tubule cells: 106 nCPM

Immune cell

non-classical monocyte: 3.8 nTPM
intermediate monocyte: 2.6 nTPM
classical monocyte: 2.4 nTPM
myeloid DC: 2.3 nTPM
NK-cell: 2.2 nTPM
eosinophil: 2.1 nTPM

Brain region

choroid plexus: 14 nTPM
cerebral cortex: 13 nTPM
white matter: 11 nTPM
medulla oblongata: 11 nTPM
midbrain: 11 nTPM
thalamus: 11 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WASHC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WASHC1 as an antibody target. Whether an autoantibody or antibody against WASHC1 could matter depends on whether native WASHC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WASHC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WASHC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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