Seroatlas · Human Serome Atlas

VMP1

Vacuole membrane protein 1

Also known as: EPG3, TANGO5, TMEM49, VMP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96GC9
Gene
VMP1
Ensembl
ENSG00000062716
Chromosome
17
Canonical length
406 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoli,Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q96GC9|VMP1
     1  MAENGKNCDQ RRVAMNKEHH NGNFTDPSSV NEKKRREREE RQNIVLWRQP LITLQYFSLE
    61  ILVILKEWTS KLWHRQSIVV SFLLLLAVLI ATYYVEGVHQ QYVQRIEKQF LLYAYWIGLG
   121  ILSSVGLGTG LHTFLLYLGP HIASVTLAAY ECNSVNFPEP PYPDQIICPD EEGTEGTISL
   181  WSIISKVRIE ACMWGIGTAI GELPPYFMAR AARLSGAEPD DEEYQEFEEM LEHAESAQDF
   241  ASRAKLAVQK LVQKVGFFGI LACASIPNPL FDLAGITCGH FLVPFWTFFG ATLIGKAIIK
   301  MHIQKIFVII TFSKHIVEQM VAFIGAVPGI GPSLQKPFQE YLEAQRQKLH HKSEMGTPQG
   361  ENWLSWMFEK LVVVMVCYFI LSIINSMAQS YAKRIQQRLN SEEKTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 59 nTPM
  • small intestine: 57 nTPM
  • rectum: 56 nTPM
  • gallbladder: 56 nTPM
  • colon: 55 nTPM
  • liver: 55 nTPM

Single-cell type

  • neutrophils: 5,582 nCPM
  • epididymal basal cells: 1,202 nCPM
  • monocytes: 1,137 nCPM
  • esophageal apical cells: 1,115 nCPM
  • endometrial glandular cells: 1,086 nCPM
  • urothelial cells: 955 nCPM

Immune cell

  • neutrophil: 3,017 nTPM
  • non-classical monocyte: 670 nTPM
  • classical monocyte: 572 nTPM
  • total PBMC: 502 nTPM
  • intermediate monocyte: 394 nTPM
  • myeloid DC: 175 nTPM

Brain region

  • thalamus: 122 nTPM
  • white matter: 121 nTPM
  • cerebral cortex: 113 nTPM
  • medulla oblongata: 105 nTPM
  • basal ganglia: 103 nTPM
  • pons: 100 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
2.25
DepMap mean gene effect
-1.08
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VMP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VMP1 as an antibody target. Whether an autoantibody or antibody against VMP1 could matter depends on whether native VMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VMP1 is annotated at the cell surface, where native VMP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VMP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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