Seroatlas · Human Serome Atlas

BCL2L11

Bcl-2-like protein 11

Also known as: B2L11_HUMAN, BIM, BimEL, BimL, BimS, BOD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43521
Gene
BCL2L11
Ensembl
ENSG00000153094
Chromosome
2
Canonical length
198 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Mitochondria

OverviewNCBI Gene

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>O43521|BCL2L11
     1  MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
    61  QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
   121  CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR
   181  MVILRLLRYI VRLVWRMH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL2L11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 38 nTPM
  • lymph node: 24 nTPM
  • tonsil: 22 nTPM
  • thyroid gland: 19 nTPM
  • thymus: 18 nTPM
  • parathyroid gland: 18 nTPM

Single-cell type

  • plasma cells: 364 nCPM
  • early spermatids: 156 nCPM
  • erythrocyte progenitors: 128 nCPM
  • monocytes: 107 nCPM
  • pdcs: 107 nCPM
  • endometrial glandular cells: 106 nCPM

Immune cell

  • non-classical monocyte: 6.1 nTPM
  • T-reg: 6 nTPM
  • neutrophil: 5.3 nTPM
  • basophil: 5.2 nTPM
  • classical monocyte: 3.8 nTPM
  • memory B-cell: 3.3 nTPM

Brain region

  • white matter: 19 nTPM
  • basal ganglia: 16 nTPM
  • medulla oblongata: 15 nTPM
  • cerebral cortex: 15 nTPM
  • pons: 14 nTPM
  • hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.89
gnomAD missense Z
0.12
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL2L11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL2L11 as an antibody target. Whether an autoantibody or antibody against BCL2L11 could matter depends on whether native BCL2L11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL2L11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCL2L11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BCL2L11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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