Seroatlas · Human Serome Atlas

PPP1CB

Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Also known as: MP, PP-1B, PP1B, PP1B_HUMAN, PP1beta, PP1c, PPP1beta

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62140
Gene
PPP1CB
Ensembl
ENSG00000213639
Chromosome
2
Canonical length
327 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>P62140|PPP1CB
     1  MADGELNVDS LITRLLEVRG CRPGKIVQMT EAEVRGLCIK SREIFLSQPI LLELEAPLKI
    61  CGDIHGQYTD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL
   121  RGNHECASIN RIYGFYDECK RRFNIKLWKT FTDCFNCLPI AAIVDEKIFC CHGGLSPDLQ
   181  SMEQIRRIMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGADV VSKFLNRHDL
   241  DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGG MMSVDETLMC SFQILKPSEK
   301  KAKYQYGGLN SGRPVTPPRT ANPPKKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1CB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
377 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 377 nTPM
  • tongue: 289 nTPM
  • esophagus: 280 nTPM
  • blood vessel: 222 nTPM
  • heart muscle: 200 nTPM
  • smooth muscle: 179 nTPM

Single-cell type

  • neutrophils: 974 nCPM
  • hematopoietic stem cells: 505 nCPM
  • salivary acinar cells: 366 nCPM
  • cdc: 301 nCPM
  • innate lymphoid cells: 296 nCPM
  • endometrial ciliated cells: 295 nCPM

Immune cell

  • non-classical monocyte: 115 nTPM
  • neutrophil: 107 nTPM
  • intermediate monocyte: 98 nTPM
  • eosinophil: 84 nTPM
  • T-reg: 75 nTPM
  • basophil: 72 nTPM

Brain region

  • white matter: 183 nTPM
  • hypothalamus: 165 nTPM
  • spinal cord: 163 nTPM
  • basal ganglia: 162 nTPM
  • medulla oblongata: 161 nTPM
  • thalamus: 147 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PPP1CB.

Disease | AllUniProt

Conditions PPP1CB is implicated in, by any mechanism.

  • Noonan syndrome-like disorder with loose anagen hair 2 (NSLH2) MIM:617506

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 370 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.15
gnomAD pLI
1
gnomAD missense Z
4.33
DepMap mean gene effect
-1.21
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1CB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1CB as an antibody target. Whether an autoantibody or antibody against PPP1CB could matter depends on whether native PPP1CB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1CB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1CB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP1CB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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