Seroatlas · Human Serome Atlas

STAP1

Signal-transducing adaptor protein 1

Also known as: BRDG1, STAP-1, STAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULZ2
Gene
STAP1
Ensembl
ENSG00000035720
Chromosome
4
Canonical length
295 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear bodies,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>Q9ULZ2|STAP1
     1  MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLIKRSGYR EYEHYWTELR GTTLFFYTDK
    61  KSIIYVDKLD IVDLTCLTEQ NSTEKNCAKF TLVLPKEEVQ LKTENTESGE EWRGFILTVT
   121  ELSVPQNVSL LPGQVIKLHE VLEREKKRRI ETEQSTSVEK EKEPTEDYVD VLNPMPACFY
   181  TVSRKEATEM LQKNPSLGNM ILRPGSDSRN YSITIRQEID IPRIKHYKVM SVGQNYTIEL
   241  EKPVTLPNLF SVIDYFVKET RGNLRPFICS TDENTGQEPS MEGRSEKLKK NPHIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 48 nTPM
  • lymph node: 38 nTPM
  • spleen: 15 nTPM
  • appendix: 15 nTPM
  • kidney: 8.6 nTPM
  • small intestine: 7.2 nTPM

Single-cell type

  • respiratory ionocytes: 1,207 nCPM
  • epididymal clear cells: 617 nCPM
  • renal collecting duct intercalated cells: 265 nCPM
  • b-cells: 193 nCPM
  • plasma cells: 186 nCPM
  • mast cells: 118 nCPM

Immune cell

  • naive B-cell: 108 nTPM
  • memory B-cell: 89 nTPM
  • NK-cell: 39 nTPM
  • eosinophil: 24 nTPM
  • naive CD4 T-cell: 7.9 nTPM
  • basophil: 5.4 nTPM

Brain region

  • hippocampal formation: 1.2 nTPM
  • pons: 0.4 nTPM
  • medulla oblongata: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • spinal cord: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STAP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 183 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAP1 as an antibody target. Whether an autoantibody or antibody against STAP1 could matter depends on whether native STAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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