Prefoldin
IPR009053
Definition
The Prefoldin/GimC family of proteins are found in eukaryotes and archaea PMID:9463374. Prefoldin is part of a molecular chaperone system that promotes the correct folding of nascent polypeptide chains. Prefoldin/GimC interacts with the nascent chain to stabilise it prior to its folding within the central cavity of a chaperonin. Prefoldin/GimC is a hexamer consisting of two types of subunits, alpha and beta. Archaeal prefoldin contains one type of alpha and one type of beta subunit PMID:11106732, while eukaryotic prefoldin/GimC contains two different but related alpha subunits and four related beta subunits PMID:12456645. The unconventional prefoldin RPB5 interactor-like protein from Drosophila (also known as URI) is a serine/threonine phosphatase inhibitor and required for germ line cell viability and differentiation. It binds to protein phosphatase 1 alpha subunits with higher affinity than the beta subunits PMID:18412953.
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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