Seroatlas · Human Serome Atlas

UXT

Protein UXT

Also known as: ART-27, STAP1, UXT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBK9
Gene: UXT
Ensembl: ENSG00000126756
Chromosome: X
Canonical length: 157 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Centriolar satellite,Basal body
Quaternary structure: Homohexamer

OverviewNCBI Gene

The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

157 residues, UniProt reviewed canonical sequence.

>Q9UBK9|UXT
     1  MATPPKRRAV EATGEKVLRY ETFISDVLQR DLRKVLDHRD KVYEQLAKYL QLRNVIERLQ
    61  EAKHSELYMQ VDLGCNFFVD TVVPDTSRIY VALGYGFFLE LTLAEALKFI DRKSSLLTEL
   121  SNSLTKDSMN IKAHIHMLLE GLRELQGLQN FPEKPHH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UXT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 200 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 200 nTPM
ovary: 180 nTPM
pancreas: 176 nTPM
thymus: 155 nTPM
adrenal gland: 148 nTPM
kidney: 146 nTPM

Single-cell type

oocytes: 396 nCPM
decidual stromal cells: 387 nCPM
esophageal apical cells: 382 nCPM
esophageal suprabasal cells: 374 nCPM
esophageal basal cells: 354 nCPM
gastric chief cells: 343 nCPM

Immune cell

naive CD4 T-cell: 304 nTPM
plasmacytoid DC: 271 nTPM
memory B-cell: 264 nTPM
naive CD8 T-cell: 256 nTPM
T-reg: 249 nTPM
total PBMC: 248 nTPM

Brain region

white matter: 54 nTPM
medulla oblongata: 48 nTPM
spinal cord: 48 nTPM
choroid plexus: 44 nTPM
cerebellum: 42 nTPM
hypothalamus: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.86
gnomAD missense Z: 0.69
DepMap mean gene effect: -1
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Prefoldin alpha-like
Prefoldin
Prefoldin subunit
Ubiquitously expressed transcript protein UXT

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UXT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UXT as an antibody target. Whether an autoantibody or antibody against UXT could matter depends on whether native UXT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UXT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UXT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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