Seroatlas · Human Serome Atlas

STX10

Syntaxin-10

Also known as: hsyn10, STX10_HUMAN, SYN10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60499
Gene: STX10
Ensembl: ENSG00000104915
Chromosome: 19
Canonical length: 249 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>O60499|STX10
     1  MSLEDPFFVV RGEVQKAVNT ARGLYQRWCE LLQESAAVGR EELDWTTNEL RNGLRSIEWD
    61  LEDLEETIGI VEANPGKFKL PAGDLQERKV FVERMREAVQ EMKDHMVSPT AVAFLERNNR
   121  EILAGKPAAQ KSPSDLLDAS AVSATSRYIE EQQATQQLIM DEQDQQLEMV SGSIQVLKHM
   181  SGRVGEELDE QGIMLDAFAQ EMDHTQSRMD GVLRKLAKVS HMTSDRRQWC AIAVLVGVLL
   241  LVLILLFSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

spleen: 79 nTPM
esophagus: 73 nTPM
liver: 72 nTPM
cerebellum: 69 nTPM
bone marrow: 68 nTPM
lung: 61 nTPM

Single-cell type

esophageal apical cells: 171 nCPM
esophageal suprabasal cells: 98 nCPM
esophageal basal cells: 87 nCPM
neutrophils: 80 nCPM
hofbauer cells: 78 nCPM
decidual stromal cells: 75 nCPM

Immune cell

neutrophil: 270 nTPM
classical monocyte: 163 nTPM
non-classical monocyte: 153 nTPM
intermediate monocyte: 129 nTPM
eosinophil: 121 nTPM
myeloid DC: 119 nTPM

Brain region

white matter: 42 nTPM
choroid plexus: 40 nTPM
cerebellum: 36 nTPM
medulla oblongata: 35 nTPM
cerebral cortex: 34 nTPM
thalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: -0.01
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX10 as an antibody target. Whether an autoantibody or antibody against STX10 could matter depends on whether native STX10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STX10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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