Seroatlas · Human Serome Atlas

STX16

Syntaxin-16

Also known as: hsyn16, STX16_HUMAN, SYN-16, SYN16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14662
Gene
STX16
Ensembl
ENSG00000124222
Chromosome
20
Canonical length
325 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>O14662|STX16
     1  MATRRLTDAF LLLRNNSIQN RQLLAEQVSS HITSSPLHSR SIAAELDELA DDRMALVSGI
    61  SLDPEAAIGV TKRPPPKWVD GVDEIQYDVG RIKQKMKELA SLHDKHLNRP TLDDSSEEEH
   121  AIEITTQEIT QLFHRCQRAV QALPSRARAC SEQEGRLLGN VVASLAQALQ ELSTSFRHAQ
   181  SGYLKRMKNR EERSQHFFDT SVPLMDDGDD NTLYHRGFTE DQLVLVEQNT LMVEEREREI
   241  RQIVQSISDL NEIFRDLGAM IVEQGTVLDR IDYNVEQSCI KTEDGLKQLH KAEQYQKKNR
   301  KMLVILILFV IIIVLIVVLV GVKSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 66 nTPM
  • spinal cord: 63 nTPM
  • cerebellum: 63 nTPM
  • spleen: 62 nTPM
  • ovary: 57 nTPM
  • cervix: 57 nTPM

Single-cell type

  • oligodendrocytes: 53 nCPM
  • choroid plexus epithelial cells: 51 nCPM
  • microglia: 50 nCPM
  • oligodendrocyte progenitor cells: 49 nCPM
  • bergmann glia: 47 nCPM
  • ependymal cells: 44 nCPM

Immune cell

  • basophil: 18 nTPM
  • neutrophil: 13 nTPM
  • classical monocyte: 5.8 nTPM
  • NK-cell: 5.4 nTPM
  • intermediate monocyte: 5.3 nTPM
  • eosinophil: 5.1 nTPM

Brain region

  • white matter: 78 nTPM
  • medulla oblongata: 70 nTPM
  • pons: 65 nTPM
  • basal ganglia: 65 nTPM
  • cerebral cortex: 64 nTPM
  • thalamus: 63 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STX16.

Disease | AllUniProt

Conditions STX16 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 293 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Pseudohypoparathyroidism type 1B

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.48
gnomAD missense Z
0.95
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX16 as an antibody target. Whether an autoantibody or antibody against STX16 could matter depends on whether native STX16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STX16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STX16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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