Seroatlas · Human Serome Atlas

VPS51

Vacuolar protein sorting-associated protein 51 homolog

Also known as: ANG2, ANG3, C11orf2, C11orf3, FFR, VPS51_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UID3
Gene
VPS51
Ensembl
ENSG00000149823
Chromosome
11
Canonical length
782 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoli,Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in retrograde transport from the early and late endosomes to the trans-Golgi network. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

782 residues, UniProt reviewed canonical sequence.

>Q9UID3|VPS51
     1  MAAAAAAGPS PGSGPGDSPE GPEGEAPERR RKAHGMLKLY YGLSEGEAAG RPAGPDPLDP
    61  TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL DSDMQTLVYE NYNKFISATD
   121  TIRKMKNDFR KMEDEMDRLA TNMAVITDFS ARISATLQDR HERITKLAGV HALLRKLQFL
   181  FELPSRLTKC VELGAYGQAV RYQGRAQAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR
   241  FREGGSGAPE QAECVELLLA LGEPAEELCE EFLAHARGRL EKELRNLEAE LGPSPPAPDV
   301  LEFTDHGGSG FVGGLCQVAA AYQELFAAQG PAGAEKLAAF ARQLGSRYFA LVERRLAQEQ
   361  GGGDNSLLVR ALDRFHRRLR APGALLAAAG LADAATEIVE RVARERLGHH LQGLRAAFLG
   421  CLTDVRQALA APRVAGKEGP GLAELLANVA SSILSHIKAS LAAVHLFTAK EVSFSNKPYF
   481  RGEFCSQGVR EGLIVGFVHS MCQTAQSFCD SPGEKGGATP PALLLLLSRL CLDYETATIS
   541  YILTLTDEQF LVQDQFPVTP VSTLCAEARE TARRLLTHYV KVQGLVISQM LRKSVETRDW
   601  LSTLEPRNVR AVMKRVVEDT TAIDVQVGLL YEEGVRKAQS SDSSKRTFSV YSSSRQQGRY
   661  APSYTPSAPM DTNLLSNIQK LFSERIDVFS PVEFNKVSVL TGIIKISLKT LLECVRLRTF
   721  GRFGLQQVQV DCHFLQLYLW RFVADEELVH LLLDEVVASA ALRCPDPVPM EPSVVEVICE
   781  RG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
123 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 123 nTPM
  • ovary: 85 nTPM
  • skeletal muscle: 84 nTPM
  • skin: 73 nTPM
  • stomach: 71 nTPM
  • blood vessel: 65 nTPM

Single-cell type

  • late spermatids: 375 nCPM
  • pancreatic acinar cells: 195 nCPM
  • colonocytes: 189 nCPM
  • enteric stem cells: 176 nCPM
  • syncytiotrophoblasts: 166 nCPM
  • enteric transient amplifying cells: 164 nCPM

Immune cell

  • NK-cell: 31 nTPM
  • memory CD8 T-cell: 27 nTPM
  • memory CD4 T-cell: 25 nTPM
  • naive CD4 T-cell: 23 nTPM
  • memory B-cell: 23 nTPM
  • myeloid DC: 22 nTPM

Brain region

  • basal ganglia: 66 nTPM
  • cerebral cortex: 65 nTPM
  • hippocampal formation: 65 nTPM
  • cerebellum: 64 nTPM
  • choroid plexus: 61 nTPM
  • white matter: 61 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VPS51.

Disease | AllUniProt

Conditions VPS51 is implicated in, by any mechanism.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 181 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Pontocerebellar hypoplasia, type 13

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
2.66
DepMap mean gene effect
-0.51
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS51 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS51 as an antibody target. Whether an autoantibody or antibody against VPS51 could matter depends on whether native VPS51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VPS51. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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