Seroatlas · Human Serome Atlas

TMEM9

Proton-transporting V-type ATPase complex assembly regulator TMEM9

Also known as: TMEM9_HUMAN, TMEM9A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0T7
Gene: TMEM9
Ensembl: ENSG00000116857
Chromosome: 1
Canonical length: 183 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Microtubules,Cytokinetic bridge,Mitotic spindle

OverviewNCBI Gene

Involved in intracellular pH reduction; positive regulation of canonical Wnt signaling pathway; and proton-transporting V-type ATPase complex assembly. Located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q9P0T7|TMEM9
     1  MKLLSLVAVV GCLLVPPAEA NKSSEDIRCK CICPPYRNIS GHIYNQNVSQ KDCNCLHVVE
    61  PMPVPGHDVE AYCLLCECRY EERSTTTIKV IIVIYLSVVG ALLLYMAFLM LVDPLIRKPD
   121  AYTEQLHNEE ENEDARSMAA AAASLGGPRA NTVLERVEGA QQRWKLQVQE QRKTVFDRHK
   181  MLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 185 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 185 nTPM
cerebral cortex: 118 nTPM
hypothalamus: 113 nTPM
basal ganglia: 109 nTPM
amygdala: 107 nTPM
hippocampal formation: 102 nTPM

Single-cell type

late spermatids: 213 nCPM
oocytes: 120 nCPM
pancreatic islet cells: 97 nCPM
early spermatids: 96 nCPM
differentiating spermatogonia: 91 nCPM
decidual stromal cells: 88 nCPM

Immune cell

total PBMC: 76 nTPM
naive CD4 T-cell: 65 nTPM
classical monocyte: 60 nTPM
plasmacytoid DC: 56 nTPM
memory B-cell: 55 nTPM
MAIT T-cell: 52 nTPM

Brain region

choroid plexus: 116 nTPM
hypothalamus: 95 nTPM
midbrain: 94 nTPM
thalamus: 86 nTPM
hippocampal formation: 84 nTPM
cerebral cortex: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 1.11
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM9 as an antibody target. Whether an autoantibody or antibody against TMEM9 could matter depends on whether native TMEM9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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