Seroatlas · Human Serome Atlas

YKT6

Synaptobrevin homolog YKT6

Also known as: YKT6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15498
Gene: YKT6
Ensembl: ENSG00000106636
Chromosome: 7
Canonical length: 198 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>O15498|YKT6
     1  MKLYSLSVLY KGEAKVVLLK AAYDVSSFSF FQRSSVQEFM TFTSQLIVER SSKGTRASVK
    61  EQDYLCHVYV RNDSLAGVVI ADNEYPSRVA FTLLEKVLDE FSKQVDRIDW PVGSPATIHY
   121  PALDGHLSRY QNPREADPMT KVQAELDETK IILHNTMESL LERGEKLDDL VSKSEVLGTQ
   181  SKAFYKTARK QNSCCAIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YKT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

midbrain: 47 nTPM
skeletal muscle: 46 nTPM
hippocampal formation: 45 nTPM
amygdala: 44 nTPM
pancreas: 44 nTPM
cerebral cortex: 44 nTPM

Single-cell type

esophageal apical cells: 170 nCPM
extravillous trophoblasts: 86 nCPM
esophageal suprabasal cells: 77 nCPM
breast lactating cells: 57 nCPM
syncytiotrophoblasts: 57 nCPM
parietal cells: 51 nCPM

Immune cell

eosinophil: 18 nTPM
intermediate monocyte: 12 nTPM
classical monocyte: 11 nTPM
non-classical monocyte: 11 nTPM
naive B-cell: 10 nTPM
myeloid DC: 10 nTPM

Brain region

midbrain: 62 nTPM
pons: 57 nTPM
thalamus: 54 nTPM
hypothalamus: 51 nTPM
spinal cord: 50 nTPM
medulla oblongata: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.36
gnomAD missense Z: 0.99
DepMap mean gene effect: -1.3
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YKT6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YKT6 as an antibody target. Whether an autoantibody or antibody against YKT6 could matter depends on whether native YKT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YKT6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YKT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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