Seroatlas · Human Serome Atlas

STXBP4

Syntaxin-binding protein 4

Also known as: MGC50337, STXB4_HUMAN, Synip

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZWJ1
Gene
STXBP4
Ensembl
ENSG00000166263
Chromosome
17
Canonical length
553 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Enables syntaxin binding activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; positive regulation of keratinocyte proliferation; and protein stabilization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q6ZWJ1|STXBP4
     1  MNKNTSTVVS PSLLEKDPAF QMITIAKETG LGLKVLGGIN RNEGPLVYIQ EIIPGGDCYK
    61  DGRLKPGDQL VSVNKESMIG VSFEEAKSII TGAKLRLESA WEIAFIRQKS DNIQPENLSC
   121  TSLIEASGEY GPQASTLSLF SSPPEILIPK TSSTPKTNND ILSSCEIKTG YNKTVQIPIT
   181  SENSTVGLSN TDVASAWTEN YGLQEKISLN PSVRFKAEKL EMALNYLGIQ PTKEQHQALR
   241  QQVQADSKGT VSFGDFVQVA RNLFCLQLDE VNVGAHEISN ILDSQLLPCD SSEADEMERL
   301  KCERDDALKE VNTLKEKLLE SDKQRKQLTE ELQNVKQEAK AVVEETRALR SRIHLAEAAQ
   361  RQAHGMEMDY EEVIRLLEAK ITELKAQLAD YSDQNKESVQ DLKKRIMVLD CQLRKSEMAR
   421  KTFEASTEKL LHFVEAIQEV FSDNSTPLSN LSERRAVLAS QTSLTPLGRN GRSIPATLAL
   481  ESKELVKSVR ALLDMDCLPY GWEEAYTADG IKYFINHVTQ TTSWIHPVMS VLNLSRSEEN
   541  EEDCSRELPN QKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STXBP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
5.7 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 5.7 nTPM
  • retina: 4.2 nTPM
  • kidney: 4 nTPM
  • seminal vesicle: 3.3 nTPM
  • thyroid gland: 2.9 nTPM
  • prostate: 2.8 nTPM

Single-cell type

  • ependymal cells: 314 nCPM
  • distal convoluted tubule cells: 230 nCPM
  • renal connecting tubule cells: 212 nCPM
  • cone photoreceptor cells: 205 nCPM
  • loop of henle epithelial cells: 201 nCPM
  • choroid plexus epithelial cells: 198 nCPM

Immune cell

  • NK-cell: 2.1 nTPM
  • basophil: 1.7 nTPM
  • naive B-cell: 1.1 nTPM
  • plasmacytoid DC: 1.1 nTPM
  • MAIT T-cell: 1 nTPM
  • gdT-cell: 0.9 nTPM

Brain region

  • choroid plexus: 22 nTPM
  • midbrain: 14 nTPM
  • white matter: 13 nTPM
  • medulla oblongata: 13 nTPM
  • hypothalamus: 12 nTPM
  • spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
0.74
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STXBP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STXBP4 as an antibody target. Whether an autoantibody or antibody against STXBP4 could matter depends on whether native STXBP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STXBP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STXBP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STXBP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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