Seroatlas · Human Serome Atlas

USE1

Vesicle transport protein USE1

Also known as: D12, MDS032, p31, SLT1, USE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZ43
Gene
USE1
Ensembl
ENSG00000053501
Chromosome
19
Canonical length
259 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable SNAP receptor activity. Predicted to be involved in several processes, including lysosomal transport; protein catabolic process; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q9NZ43|USE1
     1  MAASRLELNL VRLLSRCEAM AAEKRDPDEW RLEKYVGALE DMLQALKVHA SKPASEVINE
    61  YSWKVDFLKG MLQAEKLTSS SEKALANQFL APGRVPTTAR ERVPATKTVH LQSRARYTSE
   121  MRSELLGTDS AEPEMDVRKR TGVAGSQPVS EKQLAAELDL VLQRHQNLQE KLAEEMLGLA
   181  RSLKTNTLAA QSVIKKDNQT LSHSLKMADQ NLEKLKTESE RLEQHTQKSV NWLLWAMLII
   241  VCFIFISMIL FIRIMPKLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 57 nTPM
  • skeletal muscle: 54 nTPM
  • cerebral cortex: 54 nTPM
  • hippocampal formation: 50 nTPM
  • midbrain: 46 nTPM
  • heart muscle: 44 nTPM

Single-cell type

  • late spermatids: 226 nCPM
  • syncytiotrophoblasts: 93 nCPM
  • esophageal basal cells: 87 nCPM
  • esophageal apical cells: 81 nCPM
  • decidual stromal cells: 80 nCPM
  • esophageal suprabasal cells: 79 nCPM

Immune cell

  • memory B-cell: 140 nTPM
  • naive B-cell: 129 nTPM
  • naive CD4 T-cell: 116 nTPM
  • plasmacytoid DC: 87 nTPM
  • naive CD8 T-cell: 87 nTPM
  • T-reg: 85 nTPM

Brain region

  • white matter: 39 nTPM
  • medulla oblongata: 33 nTPM
  • basal ganglia: 33 nTPM
  • midbrain: 32 nTPM
  • pons: 32 nTPM
  • hypothalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
0.52
DepMap mean gene effect
-0.44
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Vesicle transport protein, Use1
  • Membrane fusion protein Use1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of USE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USE1 as an antibody target. Whether an autoantibody or antibody against USE1 could matter depends on whether native USE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/USE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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