Seroatlas · Human Serome Atlas

SNAP47

Synaptosomal-associated protein 47

Also known as: C1orf142, SNAP-47, SNP47_HUMAN, SVAP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SQN1
Gene: SNAP47
Ensembl: ENSG00000143740
Chromosome: 1
Canonical length: 464 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in synaptic vesicle fusion to presynaptic active zone membrane and synaptic vesicle priming. Predicted to act upstream of or within long-term synaptic potentiation. Located in BLOC-1 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>Q5SQN1|SNAP47
     1  MRAARRGLHC AGAERPRRRG RLWDSSGVPQ RQKRPGPWRT QTQEQMSRDV CIHTWPCTYY
    61  LEPKRRWVTG QLSLTSLSLR FMTDSTGEIL VSFPLSSIVE IKKEASHFIF SSITILEKGH
   121  AKHWFSSLRP SRNVVFSIIE HFWRELLLSQ PGAVADASVP RTRGEELTGL MAGSQKRLED
   181  TARVLHHQGQ QLDSVMRGLD KMESDLEVAD RLLTELESPA WWPFSSKLWK TPPETKPRED
   241  VSMTSCEPFG KEGILIKIPA VISHRTESHV KPGRLTVLVS GLEIHDSSSL LMHRFEREDV
   301  DDIKVHSPYE ISIRQRFIGK PDMAYRLISA KMPEVIPILE VQFSKKMELL EDALVLRSAR
   361  TSSPAEKSCS VWHAASGLMG RTLHREPPAG DQEGTALHLQ TSLPALSEAD TQELTQILRR
   421  MKGLALEAES ELERQDEALD GVAAAVDRAT LTIDKHNRRM KRLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNAP47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

ovary: 45 nTPM
cerebral cortex: 41 nTPM
adrenal gland: 39 nTPM
basal ganglia: 38 nTPM
heart muscle: 36 nTPM
skeletal muscle: 36 nTPM

Single-cell type

late spermatids: 142 nCPM
late primary spermatocytes: 82 nCPM
cardiomyocytes: 70 nCPM
early spermatids: 64 nCPM
breast lactating cells: 63 nCPM
ovarian stromal cells: 61 nCPM

Immune cell

T-reg: 47 nTPM
memory CD8 T-cell: 34 nTPM
eosinophil: 34 nTPM
memory CD4 T-cell: 33 nTPM
NK-cell: 31 nTPM
gdT-cell: 30 nTPM

Brain region

cerebral cortex: 40 nTPM
hippocampal formation: 38 nTPM
basal ganglia: 38 nTPM
amygdala: 30 nTPM
cerebellum: 30 nTPM
white matter: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNAP47 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNAP47 as an antibody target. Whether an autoantibody or antibody against SNAP47 could matter depends on whether native SNAP47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNAP47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNAP47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...