Seroatlas · Human Serome Atlas

LSM11

U7 snRNA-associated Sm-like protein LSm11

Also known as: FLJ38273, LSM11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P83369
Gene: LSM11
Ensembl: ENSG00000155858
Chromosome: 5
Canonical length: 360 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables U7 snRNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage; positive regulation of G1/S transition of mitotic cell cycle; and regulation of chromatin organization. Located in nuclear body. Part of U7 snRNP and telomerase holoenzyme complex. Implicated in Aicardi-Goutieres syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>P83369|LSM11
     1  MEERERGARS AGAGSPARPP SPRLDVSSDS FDPLLALYAP RLPPIPYPNA PCFNNVAEYE
    61  SFLRTGVRGG GRGRGRARGA AAGSGVPAAP GPSGRTRRRP DAPAPDPERI QRLRRLMVAK
   121  EEGDGAAGAG RRGPGRSRKA PRNVLTRMPL HEGSPLGELH RCIREGVKVN VHIRTFKGLR
   181  GVCTGFLVAF DKFWNMALTD VDETYRKPVL GKAYERDSSL TLTRLFDRLK LQDSSKKEAD
   241  SKSAVEDSTL SRYSQTSTWK LASVWGRADT GRGSHKRSRS VPSSLQASAR EESRSELSGR
   301  TTRTDGSSVG GTFSRATTLS RGQSRKKKRK PKVDYQQVFT RHINQIFIRG ENVLLVHLAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSM11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 11 nTPM
cerebellum: 7 nTPM
retina: 6.6 nTPM
colon: 6 nTPM
cerebral cortex: 5.6 nTPM
endometrium: 4.8 nTPM

Single-cell type

late spermatids: 22 nCPM
corticotrophs: 21 nCPM
smooth muscle cells: 20 nCPM
retinal bipolar cells: 17 nCPM
differentiating spermatogonia: 15 nCPM
retinal horizontal cells: 14 nCPM

Immune cell

basophil: 0.4 nTPM
NK-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

cerebral cortex: 13 nTPM
cerebellum: 11 nTPM
basal ganglia: 11 nTPM
spinal cord: 9.5 nTPM
midbrain: 9.3 nTPM
pons: 9.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LSM11.

Disease | AllUniProt

Conditions LSM11 is implicated in, by any mechanism.

Aicardi-Goutieres syndrome 8 (AGS8) MIM:619486

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 93 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Aicardi-Goutieres syndrome 8

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.6
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.69
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

U7 snRNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sm domain, eukaryotic/archaea-type
LSM domain superfamily
Sm domain
U7 snRNA-associated Sm-like protein LSM11, middle domain
U7 snRNA-associated Sm-like protein Lsm11

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LSM11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSM11 as an antibody target. Whether an autoantibody or antibody against LSM11 could matter depends on whether native LSM11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSM11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LSM11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...