AKAP7

Protein identityUniProt · HPA

UniProt accession

Q9P0M2

Gene

AKAP7

Ensembl

ENSG00000118507

Chromosome

6

Canonical length

348 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Vesicles

OverviewNCBI Gene

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q9P0M2|AKAP7
     1  MERPEAGGIN SNECENVSRK KKMSEEFEAN TMDSLVDMPF ATVDIQDDCG ITDEPQINLK
    61  RSQENEWVKS DQVKKRKKKR KDYQPNYFLS IPITNKEIIK GIKILQNAII QQDERLAKAM
   121  VSDGSFHITL LVMQLLNEDE VNIGIDALLE LKPFIEELLQ GKHLTLPFQG IGTFGNQVGF
   181  VKLAEGDHVN SLLEIAETAN RTFQEKGILV GESRSFKPHL TFMKLSKSPW LRKNGVKKID
   241  PDLYEKFISH RFGEEILYRI DLCSMLKKKQ SNGYYHCESS IVIGEKNGGE PDDAELVRLS
   301  KRLVENAVLK AVQQYLEETQ NKNKPGEGSS VKTEAADQNG NDNENNRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKAP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

54 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

0.17

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• modulation of chemical synaptic transmission

Molecular functions

• nucleotide binding
• protein kinase A binding
• protein kinase A regulatory subunit binding
• protein kinase binding

Cellular components

• cytosol
• hippocampal mossy fiber to CA3 synapse
• nucleus
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Cyclic phosphodiesterase
• A-kinase anchor protein 7-like, phosphoesterase domain
• A-kinase anchor protein 7, RI-RII subunit-binding domain
• AKAP7 2'5' RNA ligase-like domain
• PKA-RI-RII subunit binding domain of A-kinase anchor protein
• A-kinase anchor protein 7 isoform gamma

KeywordsUniProt

• Cytoplasm
• Nucleotide-binding
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of AKAP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PRKCA
• PRKACA
• SNRPF
• SPA17