Seroatlas · Human Serome Atlas

ARMCX5

Armadillo repeat-containing X-linked protein 5

Also known as: ARMX5_HUMAN, FLJ12969, GASP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P1M9
Gene
ARMCX5
Ensembl
ENSG00000125962
Chromosome
X
Canonical length
558 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Plasma membrane,Cytosol

OverviewNCBI Gene

No narrative summary is available for ARMCX5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

558 residues, UniProt reviewed canonical sequence.

>Q6P1M9|ARMCX5
     1  MVDSGTEARA RGKAEAGLQD GISGPATARV NGKTQAEAVA EAELKTESVT QAKAGDGAMT
    61  RTHTVTYREA MAVTREVIKV EDTTKTRVMV ETKTKPLAER SIVPQTKSKA MPMSRVSTVT
   121  KSEVKVVAVI EANIRSYAKS HDKANTGSRP DRREETSIGM KSSDEDEENI CSWFWTGEEP
   181  SVGSWFWPEE ETSLQVYKPL PKIQEKPKPT HKPTLTIKQK VIAWSRARYI VLVPVEGGEQ
   241  SLPPEGNWTL VETLIETPLG IRPLTKIPPY HGPYYQTLAE IKKQIRQREK YGPNPKACHC
   301  KSRGFSLEPK EFDKLVALLK LTKDPFIHEI ATMIMGISPA YPFTQDIIHD VGITVMIENL
   361  VNNPNVKEHP GALSMVDDSS ESSEEPKSGE SYIHQVCKGI ISCPLNSPVQ LAGLKLLGHL
   421  SIKFEDHYVI TSYIPDFLTL LNKGSVKTKF YVLKVFSCLS KNHANTRELI SAKVLSSLVA
   481  PFNKNESKAN ILNIIEIFEN INFQFKTKAK LFTKEKFTKS ELISIFQEAK QFGQKLQDLA
   541  EHSDPEVRDK VIRLILKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMCX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 13 nTPM
  • thyroid gland: 11 nTPM
  • breast: 11 nTPM
  • parathyroid gland: 11 nTPM
  • epididymis: 11 nTPM
  • ovary: 10 nTPM

Single-cell type

  • distal convoluted tubule cells: 6.5 nCPM
  • papillary tip epithelial cells: 5.5 nCPM
  • renal collecting duct intercalated cells: 5.4 nCPM
  • renal collecting duct principal cells: 5.4 nCPM
  • loop of henle epithelial cells: 5.3 nCPM
  • proximal tubule cells: 4.7 nCPM

Immune cell

  • naive CD4 T-cell: 9.7 nTPM
  • naive CD8 T-cell: 7.7 nTPM
  • gdT-cell: 7.3 nTPM
  • MAIT T-cell: 7 nTPM
  • intermediate monocyte: 6.9 nTPM
  • memory CD4 T-cell: 6.6 nTPM

Brain region

  • cerebral cortex: 12 nTPM
  • white matter: 11 nTPM
  • basal ganglia: 11 nTPM
  • hypothalamus: 10 nTPM
  • cerebellum: 9.8 nTPM
  • hippocampal formation: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0.03
gnomAD missense Z
1.04
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARMCX5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMCX5 as an antibody target. Whether an autoantibody or antibody against ARMCX5 could matter depends on whether native ARMCX5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMCX5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMCX5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARMCX5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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