PPP5C
Serine/threonine-protein phosphatase 5
Also known as: PP5, PPP5, PPP5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P53041
- Gene
- PPP5C
- Ensembl
- ENSG00000011485
- Chromosome
- 19
- Canonical length
- 499 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Vesicles,Cytosol
OverviewNCBI Gene
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Canonical amino-acid sequenceUniProt
499 residues, UniProt reviewed canonical sequence.
>P53041|PPP5C
1 MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS
61 NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE
121 TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK
181 LEDGKVTISF MKELMQWYKD QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC
241 GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL
301 RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG
361 VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSISKR GVSCQFGPDV TKAFLEENNL
421 DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP
481 HPNVKPMAYA NTLLQLGMMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PPP5C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 54 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 54 nTPM
- heart muscle: 51 nTPM
- tongue: 43 nTPM
- cerebral cortex: 43 nTPM
- blood vessel: 36 nTPM
- choroid plexus: 35 nTPM
Single-cell type
- cardiomyocytes: 64 nCPM
- cholangiocytes: 63 nCPM
- fallopian tube ciliated cells: 58 nCPM
- ependymal cells: 55 nCPM
- epicardial cells: 55 nCPM
- myonuclei: 54 nCPM
Immune cell
- gdT-cell: 28 nTPM
- non-classical monocyte: 24 nTPM
- NK-cell: 22 nTPM
- memory CD8 T-cell: 22 nTPM
- intermediate monocyte: 18 nTPM
- MAIT T-cell: 18 nTPM
Brain region
- cerebral cortex: 53 nTPM
- pons: 48 nTPM
- medulla oblongata: 42 nTPM
- thalamus: 42 nTPM
- basal ganglia: 39 nTPM
- hypothalamus: 39 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.21
- gnomAD pLI
- 1
- gnomAD missense Z
- 2.73
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to cadmium ion
- cellular response to hydrogen peroxide
- DNA-templated transcription
- double-strand break repair
- MAPK cascade
- mitotic cell cycle
- negative regulation of apoptotic process
- negative regulation of MAPK cascade
- peptidyl-serine dephosphorylation
- positive regulation of canonical NF-kappaB signal transduction
- positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway
- response to lead ion
- response to morphine
- response to arachidonate
Molecular functions
- ADP binding
- ATP binding
- G-protein alpha-subunit binding
- Hsp70 protein binding
- Hsp90 protein binding
- identical protein binding
- lipid binding
- metal ion binding
- microtubule binding
- mitogen-activated protein kinase kinase kinase binding
- phosphatase activity
- phosphoprotein phosphatase activity
- protein serine/threonine kinase inhibitor activity
- protein serine/threonine phosphatase activity
- protein-containing complex binding
- RNA binding
- tau protein binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Calcineurin-like, phosphoesterase domain
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- Tetratricopeptide-like helical domain superfamily
- PPP domain
- Tetratricopeptide repeat
- Metallo-dependent phosphatase-like
- Protein Phosphatase PPP
- Calcineurin-like phosphoesterase
- Tetratricopeptide repeat
- PPP5 TPR repeat region
- PP5, C-terminal metallophosphatase domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PPP5C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PPP5C as an antibody target. Whether an autoantibody or antibody against PPP5C could matter depends on whether native PPP5C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PPP5C is annotated at the cell surface, where native PPP5C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PPP5C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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