Seroatlas · Human Serome Atlas

ACAD11

Acyl-CoA dehydrogenase family member 11

Also known as: ACD11_HUMAN, FLJ12592

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q709F0
Gene: ACAD11
Ensembl: ENSG00000240303
Chromosome: 3
Canonical length: 780 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

780 residues, UniProt reviewed canonical sequence.

>Q709F0|ACAD11
     1  MKPGATGESD LAEVLPQHKF DSKSLEAYLN QHLSGFGAER EATLTIAQYR AGKSNPTFYL
    61  QKGFQTYVLR KKPPGSLLPK AHQIDREFKV QKALFSIGFP VPKPILYCSD TSVIGTEFYV
   121  MEHVQGRIFR DLTIPGLSPA ERSAIYVATV ETLAQLHSLN IQSLQLEGYG IGAGYCKRQV
   181  STWTKQYQAA AHQDIPAMQQ LSEWLMKNLP DNDNEENLIH GDFRLDNIVF HPKECRVIAV
   241  LDWELSTIGH PLSDLAHFSL FYFWPRTVPM INQGSYSENS GIPSMEELIS IYCRCRGINS
   301  ILPNWNFFLA LSYFKMAGIA QGVYSRYLLG NNSSEDSFLF ANIVQPLAET GLQLSKRTFS
   361  TVLPQIDTTG QLFVQTRKGQ EVLIKVKHFM KQHILPAEKE VTEFYVQNEN SVDKWGKPLV
   421  IDKLKEMAKV EGLWNLFLPA VSGLSHVDYA LIAEETGKCF FAPDVFNCQA PDTGNMEVLH
   481  LYGSEEQKKQ WLEPLLQGNI TSCFCMTEPD VASSDATNIE CSIQRDEDSY VINGKKWWSS
   541  GAGNPKCKIA IVLGRTQNTS LSRHKQHSMI LVPMNTPGVK IIRPLSVFGY TDNFHGGHFE
   601  IHFNQVRVPA TNLILGEGRG FEISQGRLGP GRIHHCMRTV GLAERALQIM CERATQRIAF
   661  KKKLYAHEVV AHWIAESRIA IEKIRLLTLK AAHSMDTLGS AGAKKEIAMI KVAAPRAVSK
   721  IVDWAIQVCG GAGVSQDYPL ANMYAITRVL RLADGPDEVH LSAIATMELR DQAKRLTAKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACAD11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

liver: 97 nTPM
kidney: 60 nTPM
choroid plexus: 45 nTPM
duodenum: 16 nTPM
adipose tissue: 15 nTPM
small intestine: 15 nTPM

Single-cell type

choroid plexus epithelial cells: 190 nCPM
ependymal cells: 123 nCPM
bergmann glia: 90 nCPM
brain inhibitory neurons: 85 nCPM
oligodendrocytes: 80 nCPM
astrocytes: 79 nCPM

Immune cell

naive CD4 T-cell: 1.4 nTPM
NK-cell: 0.9 nTPM
plasmacytoid DC: 0.9 nTPM
naive CD8 T-cell: 0.7 nTPM
gdT-cell: 0.6 nTPM
memory B-cell: 0.6 nTPM

Brain region

choroid plexus: 41 nTPM
basal ganglia: 16 nTPM
white matter: 16 nTPM
medulla oblongata: 14 nTPM
pons: 14 nTPM
thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACAD11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACAD11 as an antibody target. Whether an autoantibody or antibody against ACAD11 could matter depends on whether native ACAD11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACAD11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACAD11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...