Seroatlas · Human Serome Atlas

NEIL3

Endonuclease 8-like 3

Also known as: FLJ10858, FPG2, hFPG2, hNEI3, NEIL3_HUMAN, ZGRF3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAT5
Gene
NEIL3
Ensembl
ENSG00000109674
Chromosome
4
Canonical length
605 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

605 residues, UniProt reviewed canonical sequence.

>Q8TAT5|NEIL3
     1  MVEGPGCTLN GEKIRARVLP GQAVTGVRGS ALRSLQGRAL RLAASTVVVS PQAAALNNDS
    61  SQNVLSLFNG YVYSGVETLG KELFMYFGPK ALRIHFGMKG FIMINPLEYK YKNGASPVLE
   121  VQLTKDLICF FDSSVELRNS MESQQRIRMM KELDVCSPEF SFLRAESEVK KQKGRMLGDV
   181  LMDQNVLPGV GNIIKNEALF DSGLHPAVKV CQLTDEQIHH LMKMIRDFSI LFYRCRKAGL
   241  ALSKHYKVYK RPNCGQCHCR ITVCRFGDNN RMTYFCPHCQ KENPQHVDIC KLPTRNTIIS
   301  WTSSRVDHVM DSVARKSEEH WTCVVCTLIN KPSSKACDAC LTSRPIDSVL KSEENSTVFS
   361  HLMKYPCNTF GKPHTEVKIN RKTAFGTTTL VLTDFSNKSS TLERKTKQNQ ILDEEFQNSP
   421  PASVCLNDIQ HPSKKTTNDI TQPSSKVNIS PTISSESKLF SPAHKKPKTA QYSSPELKSC
   481  NPGYSNSELQ INMTDGPRTL NPDSPRCSKH NRLCILRVVG KDGENKGRQF YACPLPREAQ
   541  CGFFEWADLS FPFCNHGKRS TMKTVLKIGP NNGKNFFVCP LGKEKQCNFF QWAENGPGIK
   601  IIPGC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEIL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 22 nTPM
  • bone marrow: 6.3 nTPM
  • lymph node: 3.4 nTPM
  • tonsil: 3.3 nTPM
  • skin: 2.2 nTPM
  • appendix: 1.6 nTPM

Single-cell type

  • neutrophil progenitors: 75 nCPM
  • monocyte progenitors: 68 nCPM
  • erythrocyte progenitors: 34 nCPM
  • neutrophils: 22 nCPM
  • oocytes: 18 nCPM
  • megakaryocyte progenitors: 18 nCPM

Immune cell

  • NK-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • T-reg: 0.2 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • thalamus: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • pons: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • hypothalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
-0.15
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEIL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEIL3 as an antibody target. Whether an autoantibody or antibody against NEIL3 could matter depends on whether native NEIL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEIL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEIL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NEIL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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