CS domain
PF04969
Definition
The CS and CHORD ([pfam:PF04968]) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD PMID:10571178. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies PMID:14761955. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19) ([swissprot:O94966]), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2 PMID:21849505.
12 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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