HSP20-like chaperone
IPR008978
Definition
This homologous superfamily represents HSP20-like chaperones and related proteins. Hsp20 is a mammalian small heat-shock protein family that occurs most abundantly in skeletal muscle and heart. It has a tendency to form dimers, via a disulphide linkage formed by an N-terminal cysteine, low heat stability and a poor chaperoning ability in comparison with other family members. Structurally, this and related proteins contain a β-sandwich fold consisting of 8 strands in two β-sheets in a greek-key topology PMID:11702068.
25 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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