Seroatlas · Human Serome Atlas

SMYD2

N-lysine methyltransferase SMYD2

Also known as: HSKM-B, KMT3C, SMYD2_HUMAN, ZMYND14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRG4
Gene: SMYD2
Ensembl: ENSG00000143499
Chromosome: 1
Canonical length: 433 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>Q9NRG4|SMYD2
     1  MRAEGLGGLE RFCSPGKGRG LRALQPFQVG DLLFSCPAYA YVLTVNERGN HCEYCFTRKE
    61  GLSKCGRCKQ AFYCNVECQK EDWPMHKLEC SPMVVFGENW NPSETVRLTA RILAKQKIHP
   121  ERTPSEKLLA VKEFESHLDK LDNEKKDLIQ SDIAALHHFY SKHLGFPDND SLVVLFAQVN
   181  CNGFTIEDEE LSHLGSAIFP DVALMNHSCC PNVIVTYKGT LAEVRAVQEI KPGEEVFTSY
   241  IDLLYPTEDR NDRLRDSYFF TCECQECTTK DKDKAKVEIR KLSDPPKAEA IRDMVRYARN
   301  VIEEFRRAKH YKSPSELLEI CELSQEKMSS VFEDSNVYML HMMYQAMGVC LYMQDWEGAL
   361  QYGQKIIKPY SKHYPLYSLN VASMWLKLGR LYMGLEHKAA GEKALKKAIA IMEVAHGKDH
   421  PYISEIKQEI ESH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMYD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 184 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 184 nTPM
skeletal muscle: 87 nTPM
cerebral cortex: 32 nTPM
fallopian tube: 26 nTPM
placenta: 26 nTPM
liver: 25 nTPM

Single-cell type

cytotrophoblasts: 271 nCPM
parietal cells: 226 nCPM
migrating cytotrophoblasts: 207 nCPM
early spermatids: 207 nCPM
cardiomyocytes: 193 nCPM
respiratory ciliated cells: 188 nCPM

Immune cell

NK-cell: 29 nTPM
T-reg: 27 nTPM
memory CD4 T-cell: 23 nTPM
memory CD8 T-cell: 20 nTPM
naive CD4 T-cell: 19 nTPM
naive CD8 T-cell: 18 nTPM

Brain region

cerebral cortex: 33 nTPM
choroid plexus: 24 nTPM
midbrain: 20 nTPM
hypothalamus: 20 nTPM
medulla oblongata: 17 nTPM
spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 1.28
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMYD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMYD2 as an antibody target. Whether an autoantibody or antibody against SMYD2 could matter depends on whether native SMYD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMYD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMYD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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