Seroatlas · Human Serome Atlas

WRAP73

WD repeat-containing protein WRAP73

Also known as: WDR8, WRP73_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P2S5
Gene
WRAP73
Ensembl
ENSG00000116213
Chromosome
1
Canonical length
460 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mid piece,Principal piece

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

460 residues, UniProt reviewed canonical sequence.

>Q9P2S5|WRAP73
     1  MNFSEVFKLS SLLCKFSPDG KYLASCVQYR LVVRDVNTLQ ILQLYTCLDQ IQHIEWSADS
    61  LFILCAMYKR GLVQVWSLEQ PEWHCKIDEG SAGLVASCWS PDGRHILNTT EFHLRITVWS
   121  LCTKSVSYIK YPKACLQGIT FTRDGRYMAL AERRDCKDYV SIFVCSDWQL LRHFDTDTQD
   181  LTGIEWAPNG CVLAVWDTCL EYKILLYSLD GRLLSTYSAY EWSLGIKSVA WSPSSQFLAV
   241  GSYDGKVRIL NHVTWKMITE FGHPAAINDP KIVVYKEAEK SPQLGLGCLS FPPPRAGAGP
   301  LPSSESKYEI ASVPVSLQTL KPVTDRANPK IGIGMLAFSP DSYFLATRND NIPNAVWVWD
   361  IQKLRLFAVL EQLSPVRAFQ WDPQQPRLAI CTGGSRLYLW SPAGCMSVQV PGEGDFAVLS
   421  LCWHLSGDSM ALLSKDHFCL CFLETEAVVG TACRQLGGHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WRAP73 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 23 nTPM
  • cerebellum: 22 nTPM
  • spleen: 21 nTPM
  • pancreas: 17 nTPM
  • small intestine: 17 nTPM
  • pituitary gland: 17 nTPM

Single-cell type

  • late primary spermatocytes: 45 nCPM
  • oocytes: 41 nCPM
  • late spermatids: 37 nCPM
  • cytotrophoblasts: 25 nCPM
  • enterocytes: 25 nCPM
  • hofbauer cells: 25 nCPM

Immune cell

  • eosinophil: 70 nTPM
  • basophil: 58 nTPM
  • non-classical monocyte: 34 nTPM
  • neutrophil: 29 nTPM
  • T-reg: 27 nTPM
  • myeloid DC: 24 nTPM

Brain region

  • white matter: 17 nTPM
  • cerebellum: 16 nTPM
  • thalamus: 15 nTPM
  • cerebral cortex: 15 nTPM
  • basal ganglia: 15 nTPM
  • choroid plexus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
0.01
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WRAP73 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WRAP73 as an antibody target. Whether an autoantibody or antibody against WRAP73 could matter depends on whether native WRAP73 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WRAP73 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WRAP73 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WRAP73. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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