Seroatlas · Human Serome Atlas

GADD45G

Growth arrest and DNA damage-inducible protein GADD45 gamma

Also known as: CR6, DDIT2, GA45G_HUMAN, GADD45gamma, GRP17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95257
Gene: GADD45G
Ensembl: ENSG00000130222
Chromosome: 9
Canonical length: 159 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>O95257|GADD45G
     1  MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL NVDPDNVTFC
    61  VLAAGEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR LAAIVGAGEE AGAPGDLHCI
   121  LISNPNEDAW KDPALEKLSL FCEESRSVND WVPSITLPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GADD45G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 334 nTPM

Expression across tissuesHPA

Tissue

liver: 334 nTPM
heart muscle: 314 nTPM
blood vessel: 215 nTPM
adrenal gland: 143 nTPM
skeletal muscle: 137 nTPM
pituitary gland: 125 nTPM

Single-cell type

syncytiotrophoblasts: 1,977 nCPM
breast lactating cells: 468 nCPM
decidual stromal cells: 291 nCPM
epididymal principal cells: 281 nCPM
respiratory ionocytes: 267 nCPM
hepatocytes: 265 nCPM

Immune cell

eosinophil: 4.9 nTPM
neutrophil: 0.7 nTPM
classical monocyte: 0.2 nTPM
myeloid DC: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 40 nTPM
cerebral cortex: 29 nTPM
basal ganglia: 27 nTPM
hypothalamus: 22 nTPM
thalamus: 21 nTPM
midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.55
gnomAD missense Z: 2
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GADD45G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GADD45G as an antibody target. Whether an autoantibody or antibody against GADD45G could matter depends on whether native GADD45G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GADD45G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GADD45G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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