Seroatlas · Human Serome Atlas

SRF

Serum response factor

Also known as: MCM1, SRF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11831
Gene
SRF
Ensembl
ENSG00000112658
Chromosome
6
Canonical length
508 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>P11831|SRF
     1  MLPTQAGAAA ALGRGSALGG SLNRTPTGRP GGGGGTRGAN GGRVPGNGAG LGPGRLEREA
    61  AAAAATTPAP TAGALYSGSE GDSESGEEEE LGAERRGLKR SLSEMEIGMV VGGPEASAAA
   121  TGGYGPVSGA VSGAKPGKKT RGRVKIKMEF IDNKLRRYTT FSKRKTGIMK KAYELSTLTG
   181  TQVLLLVASE TGHVYTFATR KLQPMITSET GKALIQTCLN SPDSPPRSDP TTDQRMSATG
   241  FEETDLTYQV SESDSSGETK DTLKPAFTVT NLPGTTSTIQ TAPSTSTTMQ VSSGPSFPIT
   301  NYLAPVSASV SPSAVSSANG TVLKSTGSGP VSSGGLMQLP TSFTLMPGGA VAQQVPVQAI
   361  QVHQAPQQAS PSRDSSTDLT QTSSSGTVTL PATIMTSSVP TTVGGHMMYP SPHAVMYAPT
   421  SGLGDGSLTV LNAFSQAPST MQVSHSQVQE PGGVPQVFLT ASSGTVQIPV SAVQLHQMAV
   481  IGQQAGSSSN LTELQVVNLD TAHSTKSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
78 nTPM

Expression across tissuesHPA

Tissue

  • colon: 78 nTPM
  • blood vessel: 70 nTPM
  • endometrium: 63 nTPM
  • heart muscle: 58 nTPM
  • skeletal muscle: 52 nTPM
  • urinary bladder: 51 nTPM

Single-cell type

  • epididymal basal cells: 117 nCPM
  • breast hormone-responsive cells: 80 nCPM
  • breast secretory cells: 69 nCPM
  • basal keratinocytes: 62 nCPM
  • hepatocytes: 61 nCPM
  • neuroendocrine cells: 50 nCPM

Immune cell

  • neutrophil: 1.2 nTPM
  • plasmacytoid DC: 1 nTPM
  • eosinophil: 0.8 nTPM
  • gdT-cell: 0.8 nTPM
  • intermediate monocyte: 0.8 nTPM
  • MAIT T-cell: 0.6 nTPM

Brain region

  • cerebral cortex: 34 nTPM
  • hippocampal formation: 31 nTPM
  • white matter: 30 nTPM
  • amygdala: 28 nTPM
  • basal ganglia: 26 nTPM
  • medulla oblongata: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
2.79
DepMap mean gene effect
-0.49
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRF as an antibody target. Whether an autoantibody or antibody against SRF could matter depends on whether native SRF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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