Seroatlas · Human Serome Atlas

VPS72

Vacuolar protein sorting-associated protein 72 homolog

Also known as: Swc2, TCFL1, VPS72_HUMAN, YL-1, YL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15906
Gene
VPS72
Ensembl
ENSG00000163159
Chromosome
1
Canonical length
364 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q15906|VPS72
     1  MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ SDTEDEVDSD
    61  FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK VNTPAGSSQK AREEKALLPL
   121  ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE RQGQSRRRKG PHCERPLTQE ELLREAKITE
   181  ELNLRSLETY ERLEADKKKQ VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDIEGLDPA
   241  PSVSALTPHA GTGPVNPPAR CSRTFITFSD DATFEEWFPQ GRPPKVPVRE VCPVTHRPAL
   301  YRDPVTDIPY ATARAFKIIR EAYKKYITAH GLPPTASALG PGPPPPEPLP GSGPRALRQK
   361  IVIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS72 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 57 nTPM
  • cerebellum: 35 nTPM
  • spinal cord: 34 nTPM
  • amygdala: 33 nTPM
  • midbrain: 33 nTPM
  • cerebral cortex: 33 nTPM

Single-cell type

  • oocytes: 212 nCPM
  • syncytiotrophoblasts: 79 nCPM
  • cytotrophoblasts: 72 nCPM
  • extravillous trophoblasts: 71 nCPM
  • migrating cytotrophoblasts: 67 nCPM
  • gastric progenitor cells: 54 nCPM

Immune cell

  • eosinophil: 69 nTPM
  • NK-cell: 65 nTPM
  • T-reg: 57 nTPM
  • memory B-cell: 55 nTPM
  • basophil: 54 nTPM
  • total PBMC: 49 nTPM

Brain region

  • white matter: 33 nTPM
  • hypothalamus: 33 nTPM
  • cerebellum: 32 nTPM
  • cerebral cortex: 32 nTPM
  • pons: 30 nTPM
  • medulla oblongata: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
1.57
DepMap mean gene effect
-0.5
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS72 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS72 as an antibody target. Whether an autoantibody or antibody against VPS72 could matter depends on whether native VPS72 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS72 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS72 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VPS72. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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