Seroatlas · Human Serome Atlas

MRGBP

MRG/MORF4L-binding protein

Also known as: C20orf20, Eaf7, FLJ10914, MRG15BP, MRGBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV56
Gene: MRGBP
Ensembl: ENSG00000101189
Chromosome: 20
Canonical length: 204 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleoplasm. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q9NV56|MRGBP
     1  MGEAEVGGGG AAGDKGPGEA ATSPAEETVV WSPEVEVCLF HAMLGHKPVG VNRHFHMICI
    61  RDKFSQNIGR QVPSKVIWDH LSTMYDMQAL HESEILPFPN PERNFVLPEE IIQEVREGKV
   121  MIEEEMKEEM KEDVDPHNGA DDVFSSSGSL GKASEKSSKD KEKNSSDLGC KEGADKRKRS
   181  RVTDKVLTAN SNPSSPSAAK RRRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRGBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

testis: 46 nTPM
liver: 13 nTPM
ovary: 11 nTPM
heart muscle: 9.5 nTPM
spleen: 9.3 nTPM
skeletal muscle: 8.9 nTPM

Single-cell type

late spermatids: 708 nCPM
late primary spermatocytes: 195 nCPM
early spermatids: 111 nCPM
early primary spermatocytes: 47 nCPM
undifferentiated spermatogonia: 34 nCPM
gastric progenitor cells: 28 nCPM

Immune cell

intermediate monocyte: 1 nTPM
naive CD8 T-cell: 1 nTPM
eosinophil: 0.9 nTPM
T-reg: 0.8 nTPM
MAIT T-cell: 0.7 nTPM
memory CD8 T-cell: 0.7 nTPM

Brain region

white matter: 11 nTPM
cerebral cortex: 9.3 nTPM
cerebellum: 8.9 nTPM
thalamus: 8.5 nTPM
midbrain: 7.9 nTPM
basal ganglia: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.93
gnomAD missense Z: 2.24
DepMap mean gene effect: -0.68
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Chromatin modification-related protein Eaf7/MRGBP
Chromatin modification-related protein EAF7

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRGBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRGBP as an antibody target. Whether an autoantibody or antibody against MRGBP could matter depends on whether native MRGBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRGBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRGBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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