Seroatlas · Human Serome Atlas

NR1D2

Nuclear receptor subfamily 1 group D member 2

Also known as: BD73, EAR-1r, Hs.37288, HZF2, NR1D2_HUMAN, REVERBB, REVERBbeta, RVR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14995
Gene
NR1D2
Ensembl
ENSG00000174738
Chromosome
3
Canonical length
579 aa
Protein class
Nuclear receptors, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q14995|NR1D2
     1  MEVNAGGVIA YISSSSSASS PASCHSEGSE NSFQSSSSSV PSSPNSSNSD TNGNPKNGDL
    61  ANIEGILKND RIDCSMKTSK SSAPGMTKSH SGVTKFSGMV LLCKVCGDVA SGFHYGVHAC
   121  EGCKGFFRRS IQQNIQYKKC LKNENCSIMR MNRNRCQQCR FKKCLSVGMS RDAVRFGRIP
   181  KREKQRMLIE MQSAMKTMMN SQFSGHLQND TLVEHHEQTA LPAQEQLRPK PQLEQENIKS
   241  SSPPSSDFAK EEVIGMVTRA HKDTFMYNQE QQENSAESMQ PQRGERIPKN MEQYNLNHDH
   301  CGNGLSSHFP CSESQQHLNG QFKGRNIMHY PNGHAICIAN GHCMNFSNAY TQRVCDRVPI
   361  DGFSQNENKN SYLCNTGGRM HLVCPMSKSP YVDPHKSGHE IWEEFSMSFT PAVKEVVEFA
   421  KRIPGFRDLS QHDQVNLLKA GTFEVLMVRF ASLFDAKERT VTFLSGKKYS VDDLHSMGAG
   481  DLLNSMFEFS EKLNALQLSD EEMSLFTAVV LVSADRSGIE NVNSVEALQE TLIRALRTLI
   541  MKNHPNEASI FTKLLLKLPD LRSLNNMHSE ELLAFKVHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NR1D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 51 nTPM
  • thyroid gland: 51 nTPM
  • parathyroid gland: 50 nTPM
  • tongue: 47 nTPM
  • cerebellum: 34 nTPM
  • ovary: 33 nTPM

Single-cell type

  • endometrial glandular cells: 384 nCPM
  • endometrial ciliated cells: 194 nCPM
  • endometrial luminal cells: 193 nCPM
  • retinal bipolar cells: 184 nCPM
  • rod photoreceptor cells: 169 nCPM
  • myonuclei: 164 nCPM

Immune cell

  • MAIT T-cell: 2.6 nTPM
  • memory CD4 T-cell: 1.6 nTPM
  • gdT-cell: 1.4 nTPM
  • memory CD8 T-cell: 1.3 nTPM
  • intermediate monocyte: 1.1 nTPM
  • naive CD4 T-cell: 1.1 nTPM

Brain region

  • cerebellum: 59 nTPM
  • cerebral cortex: 46 nTPM
  • white matter: 42 nTPM
  • thalamus: 39 nTPM
  • midbrain: 35 nTPM
  • hypothalamus: 34 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NR1D2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 89 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Familial atrioventricular septal defect

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0.01
gnomAD missense Z
0.93
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NR1D2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NR1D2 as an antibody target. Whether an autoantibody or antibody against NR1D2 could matter depends on whether native NR1D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NR1D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NR1D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NR1D2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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