MYST family histone acetyltransferases
IPR050603
Definition
The MYST family of histone acetyltransferases (HATs) plays a crucial role in the regulation of gene expression through the acetylation of histone proteins, which alters chromatin structure and facilitates transcriptional activation. Members of this family are involved in various cellular processes, including DNA repair, cell cycle progression, development, and autophagy. They acetylate multiple lysine residues on histones H3, H4, and H2A, impacting epigenetic transcription initiation and elongation. Some family members also acetylate non-histone proteins, influencing activities beyond chromatin remodeling. The family's acetyltransferase activity is regulated by phosphorylation, autoacetylation, and interaction with other proteins, and can use various acyl-CoA substrates for acetylation, crotonylation, and 2-hydroxyisobutyrylation, indicating a versatile role in epigenetic and metabolic regulation.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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