GPR50
Melatonin-related receptor
Also known as: H9, Mel1c, MTR1L_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q13585
- Gene
- GPR50
- Ensembl
- ENSG00000102195
- Chromosome
- X
- Canonical length
- 617 aa
- Protein class
- G-protein coupled receptors, Plasma proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Plasma membrane
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
Canonical amino-acid sequenceUniProt
617 residues, UniProt reviewed canonical sequence.
>Q13585|GPR50
1 MGPTLAVPTP YGCIGCKLPQ PEYPPALIIF MFCAMVITIV VDLIGNSMVI LAVTKNKKLR
61 NSGNIFVVSL SVADMLVAIY PYPLMLHAMS IGGWDLSQLQ CQMVGFITGL SVVGSIFNIV
121 AIAINRYCYI CHSLQYERIF SVRNTCIYLV ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF
181 NYLNNPVFTV TIVCIHFVLP LLIVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF
241 VIFLLFAVCW CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN
301 FRREYWTIFH AMRHPIIFFS GLISDIREMQ EARTLARARA HARDQAREQD RAHACPAVEE
361 TPMNVRNVPL PGDAAAGHPD RASGHPKPHS RSSSAYRKSA STHHKSVFSH SKAASGHLKP
421 VSGHSKPASG HPKSATVYPK PASVHFKADS VHFKGDSVHF KPDSVHFKPA SSNPKPITGH
481 HVSAGSHSKS AFSAATSHPK PTTGHIKPAT SHAEPTTADY PKPATTSHPK PTAADNPELS
541 ASHCPEIPAI AHPVSDDSDL PESASSPAAG PTKPAASQLE SDTIADLPDP TVVTTSTNDY
601 HDVVVIDVED DPDEMAVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GPR50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- pituitary gland: 16 nTPM
- hypothalamus: 0.9 nTPM
- placenta: 0.4 nTPM
- esophagus: 0.1 nTPM
- lymph node: 0.1 nTPM
- smooth muscle: 0.1 nTPM
Single-cell type
- lactotrophs: 4.3 nCPM
- thyrotrophs: 0.3 nCPM
- pituicytes/fscs: 0.2 nCPM
- pituitary stem cells: 0.2 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 7.2 nTPM
- cerebral cortex: 3.2 nTPM
- medulla oblongata: 1.3 nTPM
- pons: 1.2 nTPM
- thalamus: 1.1 nTPM
- basal ganglia: 0.2 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about GPR50.
Disease | ImmuneIEDB
Conditions an epitope on GPR50 was assayed in.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.62
- gnomAD pLI
- 0.65
- gnomAD missense Z
- 0.07
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GPR50 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GPR50 as an antibody target. Whether an autoantibody or antibody against GPR50 could matter depends on whether native GPR50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GPR50 is annotated at the cell surface, where native GPR50 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GPR50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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