Histone acetyltransferase domain, MYST-type
IPR002717
Definition
Histone acetyltransferases (HATs) fall into at least four different families based on sequence conservation within the HAT domain PMID:18722564. The MYST family is the largest family of HATs and is named after the founding members: MOZ, Ybf2/ Sas3, Sas2 and Tip60. MYST proteins mediate many biological functions including gene regulation, DNA repair, cell-cycle regulation and development PMID:21132344 and have been shown to acetylate several non-histone substrates PMID:19303850. MYST proteins are autoregulated by posttranslational modifications PMID:22020126. The MYST-type HAT domain contains three regions: a central region associated with acetyl-CoA cofactor binding and catalysis in addition to flanking N- and C-terminal regions harboring respectively a C2HC-type zinc finger and a helix- turn-helix DNA-binding motif. The N- and C-terminal segments directly flanking the catalytic core are likely to play an important role in histone substrate binding [[cite:PMID:11106757], [cite:PMID:17925393]]. The catalytic mechanism for the MYST-type HAT domain is still unresolved but seems to involve a conserved glutamate that functions to abstract a proton from lysine to promote the nucleophilic attack on the acetyl carbonyl carbon of acetyl-CoA [[cite:PMID:11106757], [cite:PMID:22918831], [cite:PMID:22020126], [cite:PMID:18245364]].
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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