Paraneoplastic encephalomyelitis antigen

Definition

Many eukaryotic proteins that are either known or thought to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids [[cite:PMID:2470643], [cite:PMID:3072706]]. This region has been found in, for example, heterogeneous nuclear ribonucleoproteins, small nuclear ribonucleoproteins, pre-RNA and mRNA associated proteins, Drosophila sex determination and elav proteins, human paraneoplastic encephalomyelitis antigen HuD, and many others. The structure of an RNA-binding domain of Drosophila Sex-lethal (Sxl) protein has been determined using multi-dimensional hetero-nuclear NMR PMID:7524663. Sxl contains two RNP consensus-type RNA-binding domains (RBDs) - the determined structure represents the second of these (RBD-2) PMID:7524663. The calculated intermediate-resolution family of structures exhibits the β-α-β/β-α-β tertiary fold found in other RBD-containing proteins PMID:7524663.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• CELF2
• ELAVL1
• ELAVL2
• ELAVL3
• ELAVL4
• RBMS1
• RBMS3