Seroatlas · Human Serome Atlas

ZNF385A

Zinc finger protein 385A

Also known as: DKFZp586G1122, Hzf, Z385A_HUMAN, ZFP385, ZNF385

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PM9
Gene: ZNF385A
Ensembl: ENSG00000161642
Chromosome: 12
Canonical length: 386 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>Q96PM9|ZNF385A
     1  MILGSLSRAG PLPLLRQPPI MQPPLDLKQI LPFPLEPAPT LGLFSNYSTM DPVQKAVLSH
    61  TFGGPLLKTK RPVISCNICQ IRFNSQSQAE AHYKGNRHAR RVKGIEAAKT RGREPGVREP
   121  GDPAPPGSTP TNGDGVAPRP VSMENGLGPA PGSPEKQPGS PSPPSIPETG QGVTKGEGGT
   181  PAPASLPGGS KEEEEKAKRL LYCALCKVAV NSLSQLEAHN KGTKHKTILE ARSGLGPIKA
   241  YPRLGPPTPG EPEAPAQDRT FHCEICNVKV NSEVQLKQHI SSRRHRDGVA GKPNPLLSRH
   301  KKSRGAGELA GTLTFSKELP KSLAGGLLPS PLAVAAVMAA AAGSPLSLRP APAAPLLQGP
   361  PITHPLLHPA PGPIRTAHGP ILFSPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF385A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 233 nTPM

Expression across tissuesHPA

Tissue

retina: 233 nTPM
skin: 150 nTPM
midbrain: 101 nTPM
esophagus: 93 nTPM
basal ganglia: 87 nTPM
cerebral cortex: 84 nTPM

Single-cell type

rod photoreceptor cells: 176 nCPM
retinal bipolar cells: 166 nCPM
cone photoreceptor cells: 164 nCPM
retinal pigment epithelial cells: 149 nCPM
syncytiotrophoblasts: 141 nCPM
megakaryocytes: 111 nCPM

Immune cell

intermediate monocyte: 33 nTPM
myeloid DC: 32 nTPM
classical monocyte: 29 nTPM
non-classical monocyte: 26 nTPM
total PBMC: 17 nTPM
basophil: 3 nTPM

Brain region

thalamus: 304 nTPM
midbrain: 197 nTPM
medulla oblongata: 181 nTPM
cerebellum: 166 nTPM
spinal cord: 164 nTPM
pons: 161 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.28
gnomAD missense Z: 1.69
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF385A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ELAVL1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF385A as an antibody target. Whether an autoantibody or antibody against ZNF385A could matter depends on whether native ZNF385A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF385A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF385A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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