Seroatlas · Human Serome Atlas

PLEKHN1

Pleckstrin homology domain-containing family N member 1

Also known as: DKFZP434H2010, PKHN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q494U1
Gene: PLEKHN1
Ensembl: ENSG00000187583
Chromosome: 1
Canonical length: 611 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Enables phospholipid binding activity. Involved in 3'-UTR-mediated mRNA destabilization; positive regulation of apoptotic process; and response to hypoxia. Located in several cellular components, including cytoskeleton; cytosol; and mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>Q494U1|PLEKHN1
     1  MGNSHCVPQA PRRLRASFSR KPSLKGNRED SARMSAGLPG PEAARSGDAA ANKLFHYIPG
    61  TDILDLENQR ENLEQPFLSV FKKGRRRVPV RNLGKVVHYA KVQLRFQHSQ DVSDCYLELF
   121  PAHLYFQAHG SEGLTFQGLL PLTELSVCPL EGSREHAFQI TGPLPAPLLV LCPSRAELDR
   181  WLYHLEKQTA LLGGPRRCHS APPQRRLTRL RTASGHEPGG SAVCASRVKL QHLPAQEQWD
   241  RLLVLYPTSL AIFSEELDGL CFKGELPLRA VHINLEEKEK QIRSFLIEGP LINTIRVVCA
   301  SYEDYGHWLL CLRAVTHREG APPLPGAESF PGSQVMGSGR GSLSSGGQTS WDSGCLAPPS
   361  TRTSHSLPES SVPSTVGCSS QHTPDQANSD RASIGRRRTE LRRSGSSRSP GSKARAEGRG
   421  PVTPLHLDLT QLHRLSLESS PDAPDHTSET SHSPLYADPY TPPATSHRRV TDVRGLEEFL
   481  SAMQSARGPT PSSPLPSVPV SVPASDPRSC SSGPAGPYLL SKKGALQSRA AQRHRGSAKD
   541  GGPQPPDAPQ LVSSAREGSP EPWLPLTDGR SPRRSRDPGY DHLWDETLSS SHQKCPQLGG
   601  PEASGGLVQW I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

esophagus: 58 nTPM
skin: 48 nTPM
vagina: 25 nTPM
cervix: 24 nTPM
salivary gland: 10 nTPM
urinary bladder: 8.2 nTPM

Single-cell type

esophageal apical cells: 307 nCPM
esophageal suprabasal cells: 145 nCPM
cardiomyocytes: 132 nCPM
suprabasal keratinocytes: 74 nCPM
urothelial cells: 63 nCPM
epididymal basal cells: 50 nCPM

Immune cell

NK-cell: 0.5 nTPM
eosinophil: 0.4 nTPM
memory CD8 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM

Brain region

basal ganglia: 0.4 nTPM
cerebral cortex: 0.4 nTPM
midbrain: 0.4 nTPM
thalamus: 0.4 nTPM
amygdala: 0.3 nTPM
hippocampal formation: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -1.8
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Pleckstrin homology domain
PH-like domain superfamily
PLEKHN1, PH domain
Pleckstrin homology domain-containing family N member 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHN1 as an antibody target. Whether an autoantibody or antibody against PLEKHN1 could matter depends on whether native PLEKHN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHN1 is annotated at the cell surface, where native PLEKHN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLEKHN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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