ANP32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Also known as: AN32A_HUMAN, C15orf1, I1PP2A, LANP, MAPM, mapmodulin, PHAPI, PP32
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P39687
- Gene
- ANP32A
- Ensembl
- ENSG00000140350
- Chromosome
- 15
- Canonical length
- 249 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Centrosome,Cytosol
OverviewNCBI Gene
Enables RNA binding activity. Involved in nucleocytoplasmic transport. Located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
249 residues, UniProt reviewed canonical sequence.
>P39687|ANP32A
1 MEMGRRIHLE LRNRTPSDVK ELVLDNSRSN EGKLEGLTDE FEELEFLSTI NVGLTSIANL
61 PKLNKLKKLE LSDNRVSGGL EVLAEKCPNL THLNLSGNKI KDLSTIEPLK KLENLKSLDL
121 FNCEVTNLND YRENVFKLLP QLTYLDGYDR DDKEAPDSDA EGYVEGLDDE EEDEDEEEYD
181 EDAQVVEDEE DEDEEEEGEE EDVSGEEEED EEGYNDGEVD DEEDEEELGE EERGQKRKRE
241 PEDEGEDDDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ANP32A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 189 nTPM
Expression across tissuesHPA
Tissue
- thymus: 189 nTPM
- lymph node: 146 nTPM
- tonsil: 132 nTPM
- bone marrow: 130 nTPM
- heart muscle: 120 nTPM
- retina: 98 nTPM
Single-cell type
- neutrophils: 1,468 nCPM
- neutrophil progenitors: 484 nCPM
- megakaryocytes: 359 nCPM
- cytotrophoblasts: 341 nCPM
- hofbauer cells: 299 nCPM
- monocyte progenitors: 294 nCPM
Immune cell
- eosinophil: 45 nTPM
- intermediate monocyte: 31 nTPM
- myeloid DC: 30 nTPM
- NK-cell: 29 nTPM
- non-classical monocyte: 28 nTPM
- neutrophil: 27 nTPM
Brain region
- white matter: 102 nTPM
- medulla oblongata: 92 nTPM
- spinal cord: 90 nTPM
- cerebellum: 86 nTPM
- basal ganglia: 81 nTPM
- hypothalamus: 78 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.22
- gnomAD pLI
- 0.99
- gnomAD missense Z
- 2.53
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ANP32A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ANP32A as an antibody target. Whether an autoantibody or antibody against ANP32A could matter depends on whether native ANP32A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ANP32A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ANP32A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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