Melanoma-associated antigen
IPR037445
Definition
The melanoma antigen (MAGE) protein family contains more than 25 members that share a conserved MAGE homology domain (MHD) PMID:11454705. Proteins known to contain a MAGE domain are listed below: Human MAGE-A, -B and -C proteins. MAGE-A, -B and -C genes are silent in all normal tissues with the exception of testis. Human MAGE-D to -L proteins. MAGE-D to -L genes are expressed in normal adult tissues. Mouse Mage-a and -b proteins. Mouse Mage-d, -e, -g, -h, -k and -l. Mammalian Necdin. The human Necdin gene is a candidate for the Prader-Willi syndrome. Human Trophinin mediates apical cell adhesion between trophoblastic cells and luminal epithelial cells of the endometrium and is implicated in the initial attachment during the process of human embryo implantation PMID:11590179.
36 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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