Seroatlas · Human Serome Atlas

MAGEB6

Melanoma-associated antigen B6

Also known as: CT3.4, FLJ40242, MAGB6_HUMAN, MAGE-B6, MAGEB6A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7X4
Gene: MAGEB6
Ensembl: ENSG00000176746
Chromosome: X
Canonical length: 407 aa
Protein class: Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is expressed in testis, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q8N7X4|MAGEB6
     1  MPRGHKSKLR TCEKRQETNG QPQGLTGPQA TAEKQEESHS SSSSSRACLG DCRRSSDASI
    61  PQESQGVSPT GSPDAVVSYS KSDVAANGQD EKSPSTSRDA SVPQESQGAS PTGSPDAGVS
   121  GSKYDVAANG QDEKSPSTSH DVSVPQESQG ASPTGSPDAG VSGSKYDVAA EGEDEESVSA
   181  SQKAIIFKRL SKDAVKKKAC TLAQFLQKKF EKKESILKAD MLKCVRREYK PYFPQILNRT
   241  SQHLVVAFGV ELKEMDSSGE SYTLVSKLGL PSEGILSGDN ALPKSGLLMS LLVVIFMNGN
   301  CATEEEVWEF LGLLGIYDGI LHSIYGDARK IITEDLVQDK YVVYRQVCNS DPPCYEFLWG
   361  PRAYAETTKM RVLRVLADSS NTSPGLYPHL YEDALIDEVE RALRLRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEB6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 3 nTPM

Expression across tissuesHPA

Tissue

testis: 3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early primary spermatocytes: 30 nCPM
differentiating spermatogonia: 9.6 nCPM
undifferentiated spermatogonia: 8.2 nCPM
late primary spermatocytes: 6.1 nCPM
early spermatids: 1.2 nCPM
late spermatids: 0.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.51
DepMap mean gene effect: 0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transcription by RNA polymerase II

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Tumor antigen

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEB6 as an antibody target. Whether an autoantibody or antibody against MAGEB6 could matter depends on whether native MAGEB6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEB6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEB6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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