Seroatlas · Human Serome Atlas

MAGEH1

Melanoma-associated antigen H1

Also known as: 1-Apr, MAGH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H213
Gene: MAGEH1
Ensembl: ENSG00000187601
Chromosome: X
Canonical length: 219 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoli,Nucleoli rim

OverviewNCBI Gene

This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q9H213|MAGEH1
     1  MPRGRKSRRR RNARAAEENR NNRKIQASEA SETPMAASVV ASTPEDDLSG PEEDPSTPEE
    61  ASTTPEEASS TAQAQKPSVP RSNFQGTKKS LLMSILALIF IMGNSAKEAL VWKVLGKLGM
   121  QPGRQHSIFG DPKKIVTEEF VRRGYLIYKP VPRSSPVEYE FFWGPRAHVE SSKLKVMHFV
   181  ARVRNRCSKD WPCNYDWDSD DDAEVEAILN SGARGYSAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 487 nTPM

Expression across tissuesHPA

Tissue

epididymis: 487 nTPM
choroid plexus: 88 nTPM
hypothalamus: 68 nTPM
cerebral cortex: 65 nTPM
pituitary gland: 53 nTPM
hippocampal formation: 49 nTPM

Single-cell type

epididymal principal cells: 973 nCPM
epididymal clear cells: 337 nCPM
decidual stromal cells: 82 nCPM
retinal pigment epithelial cells: 68 nCPM
hepatic stellate cells: 65 nCPM
epididymal efferent duct absorptive cells: 62 nCPM

Immune cell

T-reg: 52 nTPM
naive CD4 T-cell: 48 nTPM
memory CD4 T-cell: 36 nTPM
naive CD8 T-cell: 31 nTPM
plasmacytoid DC: 29 nTPM
memory CD8 T-cell: 25 nTPM

Brain region

hypothalamus: 82 nTPM
choroid plexus: 81 nTPM
white matter: 56 nTPM
midbrain: 55 nTPM
cerebral cortex: 55 nTPM
basal ganglia: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0.23
gnomAD missense Z: 0.62
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEH1 as an antibody target. Whether an autoantibody or antibody against MAGEH1 could matter depends on whether native MAGEH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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