MAGEA1

Protein identityUniProt · HPA

UniProt accession

P43355

Gene

MAGEA1

Ensembl

ENSG00000198681

Chromosome

X

Canonical length

309 aa

Protein class

Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>P43355|MAGEA1
     1  MSLEQRSLHC KPEEALEAQQ EALGLVCVQA ATSSSSPLVL GTLEEVPTAG STDPPQSPQG
    61  ASAFPTTINF TRQRQPSEGS SSREEEGPST SCILESLFRA VITKKVADLV GFLLLKYRAR
   121  EPVTKAEMLE SVIKNYKHCF PEIFGKASES LQLVFGIDVK EADPTGHSYV LVTCLGLSYD
   181  GLLGDNQIMP KTGFLIIVLV MIAMEGGHAP EEEIWEELSV MEVYDGREHS AYGEPRKLLT
   241  QDLVQEKYLE YRQVPDSDPA RYEFLWGPRA LAETSYVKVL EYVIKVSARV RFFFPSLREA
   301  ALREEEEGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

4.4 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAGEA1.

Disease | ImmuneIEDB

Conditions an epitope on MAGEA1 was assayed in.

• hepatocellular carcinoma T cell
• melanoma T cell
• skin melanoma T cell
• anaplastic oligodendroglioma T cell
• testicular germ cell cancer T cell
• lung non-small cell carcinoma T cell
• ovarian serous carcinoma T cell
• liver cirrhosis T cell
• hepatitis B T cell
• hepatitis C T cell
• cancer T cell
• colorectal cancer T cell
• pancreatic adenocarcinoma T cell
• brain glioblastoma multiforme T cell
• anaplastic astrocytoma T cell

ReferencesPubMed · IEDB

Publications for MAGEA1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z

0.98

DepMap mean gene effect

0.18

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of Notch signaling pathway
• negative regulation of transcription by RNA polymerase II

Molecular functions

• histone deacetylase binding

Cellular components

• cytoplasm
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• MAGE homology domain
• Melanoma associated antigen, N-terminal
• Melanoma-associated antigen
• MAGE homology domain, winged helix WH1 motif
• MAGE homology domain, winged helix WH2 motif
• MAGE homology domain
• Melanoma associated antigen family N terminal

KeywordsUniProt

• Cytoplasm
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation
• Tumor antigen

InteractionsUniProt · HPA

Protein binding partners of MAGEA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HDCA1
• SNW1
• SH3GLB2
• TRIM31