Seroatlas · Human Serome Atlas

MAGEB6B

Melanoma-associated antigen B6B

Also known as: MAB6B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0J9YX57
Gene
MAGEB6B
Canonical length
407 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MAGEB6B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>A0A0J9YX57|MAGEB6B
     1  MPRGQKSKLR ARGKRRETHD QPQGLTGPQA TAEKQEESRS SSSSSAVCQG ARRRSSGSSV
    61  PQESQGASPT GYPDAGASCS KYDVAAMGQD EKSPSTSRDA SVSQESQGAS PIGPPDAGIS
   121  CSKSDEAAKG QNEKSPSTSR DASVPQESQG ASPTGSPDAD VSGSKSDVAA KGQDEESLSS
   181  SKRAAFFTTT DGDPIKRKAN KMVQFLQKKF EKKEPILKAD MLKRLRRQYK PCFPEILKRT
   241  SEHLTVFFGV ELKETDSSGE SYTLVSKLGL SNEGSLSGDN ALPKSGLLMS ILGLIFMRGN
   301  RATEEEVWKF LGLLGIYDGI LHSIYGDARK IITEDLVQDK YVVYRQVCNS DPPCYEFLWG
   361  PRAYAETTKM RVLRVLAEIN NTSPGLYPHL YEDALTDEVE RALRLRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEB6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.5 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early primary spermatocytes: 5.5 nCPM
  • undifferentiated spermatogonia: 0.5 nCPM
  • pericytes: 0.2 nCPM
  • differentiating spermatogonia: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEB6B as an antibody target. Whether an autoantibody or antibody against MAGEB6B could matter depends on whether native MAGEB6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEB6B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEB6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAGEB6B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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