Seroatlas · Human Serome Atlas

MAGEE2

Melanoma-associated antigen E2

Also known as: HCA3, MAGE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD90
Gene: MAGEE2
Ensembl: ENSG00000186675
Chromosome: X
Canonical length: 523 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q8TD90|MAGEE2
     1  MSLVSQNARH CSAEITADYG DGRGEIQATN ASGSPTSMLV VDAPQCPQAP INSQCVNTSQ
    61  AVQDPNDLEV LIDEQSRRLG ALRVHDPLED RSIALVNFMR MKSQTEGSIQ QSEMLEFLRE
   121  YSDQFPEILR RASAHLDQVF GLNLRVIDPQ ADTYNLVSKR GFQITDRIAE SLDMPKASLL
   181  ALVLGHILLN GNRAREASIW DLLLKVDMWD KPQRINNLFG NTRNLLTTDF VCMRFLEYWP
   241  VYGTNPLEFE FLWGSRAHRE ITKMEALKFV SDAHDEEPWS WPEEYNKALE GDKTKERSLT
   301  AGLEFWSEDT MNDKANDLVQ LAISVTEEML PIHQDELLAH TGKEFEDVFP NILNRATLIL
   361  DMFYGLSLIE VDTSEHIYLL VQQPESEEEQ VMLESLGRPT QEYVMPILGL IFLMGNRVKE
   421  ANVWNLLRRF SVDVGRKHSI TRKLMRQRYL ECRPLSYSNP VEYELLWGPR AHHETIKMKV
   481  LEYMARLYRK RPQNWPEQYR EAVEDEEARA KSEATIMFFL DPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 4.1 nTPM
hypothalamus: 3.2 nTPM
cerebral cortex: 2.7 nTPM
basal ganglia: 1.9 nTPM
amygdala: 1.2 nTPM
hippocampal formation: 1.1 nTPM

Single-cell type

epicardial cells: 2.3 nCPM
other brain neurons: 1.9 nCPM
brain excitatory neurons: 1.2 nCPM
brain inhibitory neurons: 1 nCPM
retinal bipolar cells: 0.9 nCPM
granulosa cells: 0.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 7.9 nTPM
basal ganglia: 6.4 nTPM
cerebral cortex: 6.1 nTPM
cerebellum: 5.5 nTPM
medulla oblongata: 5.4 nTPM
midbrain: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
gnomAD missense Z: -1.74
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEE2 as an antibody target. Whether an autoantibody or antibody against MAGEE2 could matter depends on whether native MAGEE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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