Seroatlas · Human Serome Atlas

MAGEC3

Melanoma-associated antigen C3

Also known as: CT7.2, HCA2, MAGC3_HUMAN, MAGE-C3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD91
Gene: MAGEC3
Ensembl: ENSG00000165509
Chromosome: X
Canonical length: 643 aa
Protein class: Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

643 residues, UniProt reviewed canonical sequence.

>Q8TD91|MAGEC3
     1  MLLPCHWVLD ATFSDGSLGQ WVKNTCATYA LSPVVLPPQP QPRKKATDKD YSAFHLGHLR
    61  EVRLFLRGGT SDQRMDSLVL CPTYFKLWRT LSGSPGLQLS DLHFGSQPEG KFSLRRAVSV
   121  KQREEPQDWP LNEKRTLWKD SDLPTWRRGT GYTLSLPAVS PGKRLWGEKA GSLPESEPLF
   181  TYTLDEKVDK LVQFLLLKYQ AKEPLTRAEM QMNVINTYTG YFPMIFRKAR EFIEILFGIS
   241  LTEVDPDHFY VFVNTLDLTC EGSLSDEQGM PQNRLLILIL SVIFIKGNCA SEEVIWEVLN
   301  AIGPWSALAG FADVLSRLAL WESEGPEAFC EESGLRSAEG SVLDLANPQG LAGHRQEDGR
   361  RGLTEASPQQ KKGGEDEDMP AAGMPPLPQS PPEIPPQGPP KISPQGPPQS PPQSPLDSCS
   421  SPLLWTRLDE ESSSEEEDTA TWHALPESES LPRYALDEKV AELVQFLLLK YQTKEPVTKA
   481  EMLTTVIKKY KDYFPMIFGK AHEFIELIFG IALTDMDPDN HSYFFEDTLD LTYEGSLIDD
   541  QGMPKNCLLI LILSMIFIKG SCVPEEVIWE VLSAIGPIQR PAREVLEFLS KLSSIIPSAF
   601  PSWYMDALKD MEDRAQAIID TTDDATAMAS ASPSVMSTNF CPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 3.6 nTPM
hippocampal formation: 2.4 nTPM
blood vessel: 2 nTPM
midbrain: 1.9 nTPM
basal ganglia: 1.8 nTPM
cerebral cortex: 1.5 nTPM

Single-cell type

oligodendrocytes: 34 nCPM
brain inhibitory neurons: 13 nCPM
brain excitatory neurons: 13 nCPM
undifferentiated spermatogonia: 12 nCPM
somatotrophs: 11 nCPM
adrenal medulla cells: 11 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 8.7 nTPM
cerebral cortex: 3.5 nTPM
hypothalamus: 3.4 nTPM
pons: 3 nTPM
medulla oblongata: 2.8 nTPM
basal ganglia: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: -0.95
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transcription by RNA polymerase II

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEC3 as an antibody target. Whether an autoantibody or antibody against MAGEC3 could matter depends on whether native MAGEC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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