Seroatlas · Human Serome Atlas

MAGEF1

Melanoma-associated antigen F1

Also known as: MAGF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAY2
Gene: MAGEF1
Ensembl: ENSG00000177383
Chromosome: 3
Canonical length: 307 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments

OverviewNCBI Gene

This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in normal tissues and in tumor cells. This gene includes a microsatellite repeat in the coding region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q9HAY2|MAGEF1
     1  MLQTPESRGL PVPQAEGEKD GGHDGETRAP TASQERPKEE LGAGREEGAA EPALTRKGAR
    61  ALAAKALARR RAYRRLNRTV AELVQFLLVK DKKKSPITRS EMVKYVIGDL KILFPDIIAR
   121  AAEHLRYVFG FELKQFDRKH HTYILINKLK PLEEEEEEDL GGDGPRLGLL MMILGLIYMR
   181  GNSAREAQVW EMLRRLGVQP SKYHFLFGYP KRLIMEDFVQ QRYLSYRRVP HTNPPEYEFS
   241  WGPRSNLEIS KMEVLGFVAK LHKKEPQHWP VQYREALADE ADRARAKARA EASMRARASA
   301  RAGIHLW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 52 nTPM
choroid plexus: 44 nTPM
hypothalamus: 43 nTPM
cerebral cortex: 42 nTPM
cerebellum: 41 nTPM
basal ganglia: 37 nTPM

Single-cell type

hofbauer cells: 130 nCPM
respiratory ionocytes: 127 nCPM
cytotrophoblasts: 124 nCPM
migrating cytotrophoblasts: 103 nCPM
epididymal principal cells: 75 nCPM
retinal pigment epithelial cells: 73 nCPM

Immune cell

naive CD4 T-cell: 6.1 nTPM
myeloid DC: 5.7 nTPM
naive B-cell: 4.8 nTPM
naive CD8 T-cell: 3.1 nTPM
memory B-cell: 2.8 nTPM
eosinophil: 2.5 nTPM

Brain region

hypothalamus: 53 nTPM
choroid plexus: 40 nTPM
thalamus: 38 nTPM
cerebral cortex: 38 nTPM
midbrain: 37 nTPM
spinal cord: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAGEF1.

Disease | ImmuneIEDB

Conditions an epitope on MAGEF1 was assayed in.

glioblastoma T cell
melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAGEF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEF1 as an antibody target. Whether an autoantibody or antibody against MAGEF1 could matter depends on whether native MAGEF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...