MAGEA8

Protein identityUniProt · HPA

UniProt accession

P43361

Gene

MAGEA8

Ensembl

ENSG00000156009

Chromosome

X

Canonical length

318 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>P43361|MAGEA8
     1  MLLGQKSQRY KAEEGLQAQG EAPGLMDVQI PTAEEQKAAS SSSTLIMGTL EEVTDSGSPS
    61  PPQSPEGASS SLTVTDSTLW SQSDEGSSSN EEEGPSTSPD PAHLESLFRE ALDEKVAELV
   121  RFLLRKYQIK EPVTKAEMLE SVIKNYKNHF PDIFSKASEC MQVIFGIDVK EVDPAGHSYI
   181  LVTCLGLSYD GLLGDDQSTP KTGLLIIVLG MILMEGSRAP EEAIWEALSV MGLYDGREHS
   241  VYWKLRKLLT QEWVQENYLE YRQAPGSDPV RYEFLWGPRA LAETSYVKVL EHVVRVNARV
   301  RISYPSLHEE ALGEEKGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

13 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAGEA8.

Disease | ImmuneIEDB

Conditions an epitope on MAGEA8 was assayed in.

• colon adenocarcinoma T cell
• skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z

0.33

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of transcription by RNA polymerase II

Molecular functions

• histone deacetylase binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• MAGE homology domain
• Melanoma associated antigen, N-terminal
• Melanoma-associated antigen
• MAGE homology domain, winged helix WH1 motif
• MAGE homology domain, winged helix WH2 motif
• MAGE homology domain
• Melanoma associated antigen family N terminal

KeywordsUniProt

• Tumor antigen

InteractionsUniProt · HPA

Protein binding partners of MAGEA8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BEX5
• GCA
• MLH1