Seroatlas · Human Serome Atlas

MAGEB3

Melanoma-associated antigen B3

Also known as: CT3.5, MAGB3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15480
Gene: MAGEB3
Ensembl: ENSG00000198798
Chromosome: X
Canonical length: 346 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>O15480|MAGEB3
     1  MPRGQKSTLH AREKRQQTRG QTQDHQGAQI TATNKKKVSF SSPLILGATI QKKSAGRSRS
    61  ALKKPQRALS TTTSVDVSYK KSYKGANSKI EKKQSFSQGL SSTVQSRTDP LIMKTNMLVQ
   121  FLMEMYKMKK PIMKADMLKI VQKSHKNCFP EILKKASFNM EVVFGVDLKK VDSTKDSYVL
   181  VSKMDLPNNG TVTRGRGFPK TGLLLNLLGV IFMKGNCATE EKIWEFLNKM RIYDGKKHFI
   241  FGEPRKLITQ DLVKLKYLEY RQVPNSNPAR YEFLWGPRAH AETSKMKVLE FWAKVNKTVP
   301  SAFQFWYEEA LRDEEERVQA AAMLNDGSSA MGRKCSKAKA SSSSHA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

epididymis: 17 nTPM
testis: 4.7 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

epididymal principal cells: 22 nCPM
early primary spermatocytes: 19 nCPM
sertoli cells: 13 nCPM
adrenal medulla cells: 11 nCPM
differentiating spermatogonia: 6.3 nCPM
undifferentiated spermatogonia: 3.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.3 nTPM
basal ganglia: 0.2 nTPM
hypothalamus: 0.2 nTPM
medulla oblongata: 0.2 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0.43
gnomAD missense Z: 0.65
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transcription by RNA polymerase II

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Tumor antigen

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEB3 as an antibody target. Whether an autoantibody or antibody against MAGEB3 could matter depends on whether native MAGEB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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