MAGEA2

Protein identityUniProt · HPA

UniProt accession

P43356

Gene

MAGEA2

Ensembl

ENSG00000268606

Chromosome

X

Canonical length

314 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>P43356|MAGEA2
     1  MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQQTAS SSSTLVEVTL GEVPAADSPS
    61  PPHSPQGASS FSTTINYTLW RQSDEGSSNQ EEEGPRMFPD LESEFQAAIS RKMVELVHFL
   121  LLKYRAREPV TKAEMLESVL RNCQDFFPVI FSKASEYLQL VFGIEVVEVV PISHLYILVT
   181  CLGLSYDGLL GDNQVMPKTG LLIIVLAIIA IEGDCAPEEK IWEELSMLEV FEGREDSVFA
   241  HPRKLLMQDL VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHT LKIGGEPHIS
   301  YPPLHERALR EGEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

1.8 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAGEA2.

Disease | ImmuneIEDB

Conditions an epitope on MAGEA2 was assayed in.

• melanoma T cell
• skin melanoma T cell
• prostate cancer T cell
• breast cancer T cell
• lung non-small cell carcinoma T cell
• malignant pleural mesothelioma T cell

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular senescence
• negative regulation of protein acetylation
• negative regulation of protein sumoylation
• negative regulation of transcription by RNA polymerase II
• positive regulation of ubiquitin-protein transferase activity
• protein catabolic process
• signal transduction by p53 class mediator

Molecular functions

• DNA-binding transcription factor binding
• histone deacetylase binding
• ubiquitin protein ligase binding

Cellular components

• nucleus
• PML body

Protein domainsUniProt · Pfam · InterPro

• MAGE homology domain
• Melanoma associated antigen, N-terminal
• Melanoma-associated antigen
• MAGE homology domain, winged helix WH1 motif
• MAGE homology domain, winged helix WH2 motif
• MAGE homology domain
• Melanoma associated antigen family N terminal

KeywordsUniProt

• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation
• Tumor antigen
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of MAGEA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HDAC3
• PML
• TRIM28
• UBE2H
• SEPTIN5