Seroatlas · Human Serome Atlas

MAGEB17

Melanoma-associated antigen B17

Also known as: MAGBH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MXT2
Gene
MAGEB17
Ensembl
ENSG00000182798
Chromosome
X
Canonical length
336 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>A8MXT2|MAGEB17
     1  MPRGQASKRR AREKRRQARG EDQCLGGAQA TAAEKEKLPS SSSPACQSPP QSFPNAGIPQ
    61  ESQRASYPSS PASAVSLTSS DEGAKGQKGE SPNSFHGPSS SESTGRDLLN TKTGELVQFL
   121  LNKYIRKEPI TREAMLKVIN RKYKQHFPEI LRRSTENVEV VFGLYLKEMD PSRQSYVLVG
   181  KLDFPNQGSL SDGGGFPLSG LLMVLLSTIF MHGNRATEEE MWECLNALGM YKGRKHFIYG
   241  EPQELVTKDL VREGYLEYQQ VPSSDPPRYE FLWGPRARAE TSKMKVLEFV AKLNDTVAST
   301  YKSRYEEALR EEEEQARARA VARDSARARA SRSFQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEB17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
1.9 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 1.9 nTPM
  • testis: 1.6 nTPM
  • stomach: 0.4 nTPM
  • epididymis: 0.3 nTPM
  • colon: 0.2 nTPM
  • prostate: 0.2 nTPM

Single-cell type

  • early primary spermatocytes: 10 nCPM
  • retinal pigment epithelial cells: 4.3 nCPM
  • thymic myoid cells: 1.4 nCPM
  • differentiating spermatogonia: 1.1 nCPM
  • sertoli cells: 1.1 nCPM
  • neuroendocrine cells: 0.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0.3 nTPM
  • medulla oblongata: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.64
DepMap mean gene effect
0.13
DepMap dependency class
none

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEB17 as an antibody target. Whether an autoantibody or antibody against MAGEB17 could matter depends on whether native MAGEB17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEB17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEB17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAGEB17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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