Seroatlas · Human Serome Atlas

NDN

Necdin

Also known as: HsT16328, NECD_HUMAN, PWCR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99608
Gene
NDN
Ensembl
ENSG00000182636
Chromosome
15
Canonical length
321 aa
Protein class
Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q99608|NDN
     1  MSEQSKDLSD PNFAAEAPNS EVHSSPGVSE GVPPSATLAE PQSPPLGPTA APQAAPPPQA
    61  PNDEGDPKAL QQAAEEGRAH QAPSAAQPGP APPAPAQLVQ KAHELMWYVL VKDQKKMIIW
   121  FPDMVKDVIG SYKKWCRSIL RRTSLILARV FGLHLRLTSL HTMEFALVKA LEPEELDRVA
   181  LSNRMPMTGL LLMILSLIYV KGRGARESAV WNVLRILGLR PWKKHSTFGD VRKLITEEFV
   241  QMNYLKYQRV PYVEPPEYEF FWGSRASREI TKMQIMEFLA RVFKKDPQAW PSRYREALEE
   301  ARALREANPT AHYPRSSVSE D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
90 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 90 nTPM
  • basal ganglia: 84 nTPM
  • cervix: 76 nTPM
  • ovary: 64 nTPM
  • endometrium: 61 nTPM
  • pituitary gland: 54 nTPM

Single-cell type

  • other brain neurons: 114 nCPM
  • brain inhibitory neurons: 44 nCPM
  • oligodendrocytes: 23 nCPM
  • oligodendrocyte progenitor cells: 23 nCPM
  • ependymal cells: 21 nCPM
  • brain excitatory neurons: 21 nCPM

Immune cell

  • plasmacytoid DC: 1.5 nTPM
  • myeloid DC: 0.8 nTPM
  • intermediate monocyte: 0.3 nTPM
  • non-classical monocyte: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • NK-cell: 0.1 nTPM

Brain region

  • hypothalamus: 167 nTPM
  • pons: 75 nTPM
  • basal ganglia: 66 nTPM
  • midbrain: 64 nTPM
  • cerebral cortex: 60 nTPM
  • spinal cord: 54 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NDN.

Disease | ImmuneIEDB

Conditions an epitope on NDN was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.67
gnomAD missense Z
0.71
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDN as an antibody target. Whether an autoantibody or antibody against NDN could matter depends on whether native NDN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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